ENSDARG00000011257


Danio rerio

Features
Gene ID: ENSDARG00000011257
  
Biological name :enpp2
  
Synonyms : ectonucleotide pyrophosphatase/phosphodiesterase 2 / enpp2
  
Possible biological names infered from orthology : Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 / Q13822 / Q9R1E6
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 9609721
Gene end: 9662205
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000047919
NCBI entrez gene - 100332039     See in Manteia.
RefSeq - XM_009292082
RefSeq - NM_200603
RefSeq Peptide - NP_956897
swissprot - Q6PGY9
ZFIN ID - ZDB-GENE-040426-1156
Ensembl - ENSDARG00000011257
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENPP2ENSGALG00000032746Gallus gallus
 ENPP2ENSG00000136960Homo sapiens
 Enpp2ENSMUSG00000022425Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
enpp1 / ectonucleotide pyrophosphatase/phosphodiesterase 1 / P22413* / ectonucleotide pyrophosphatase/phosphodiesterase family member 1 isoform 3 *ENSDARG0000000578943
enpp4 / Q566N0 / ectonucleotide pyrophosphatase/phosphodiesterase 4 / Q9Y6X5* / Q8BTJ4* / Mus musculus ectonucleotide pyrophosphatase/phosphodiesterase 4 (Enpp4), transcript variant 2, mRNA.*ENSDARG0000000687715
enpp5 / ectonucleotide pyrophosphatase/phosphodiesterase 5 / Q9EQG7* / Q9UJA9* / ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative)* / Mus musculus ectonucleotide pyrophosphatase...ENSDARG0000007062514
enpp7.2 / ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 2 / ENPP7* / Q6UWV6* / ectonucleotide pyrophosphatase/phosphodiesterase 7*ENSDARG0000005352513
enpp7.1 / ectonucleotide pyrophosphatase/phosphodiesterase 7, tandem duplicate 1 / ENPP7* / Q6UWV6* / ectonucleotide pyrophosphatase/phosphodiesterase 7*ENSDARG0000005352613
zgc:153896ENSDARG0000000397712
enpp6 / ectonucleotide pyrophosphatase/phosphodiesterase 6 / Q6UWR7* / Q8BGN3* / Ectonucleotide pyrophosphatase/phosphodiesterase family member 6 *ENSDARG0000004046912


Protein motifs (from Interpro)
Interpro ID Name
 IPR001212  Somatomedin B domain
 IPR001604  DNA/RNA non-specific endonuclease
 IPR002591  Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase
 IPR017849  Alkaline phosphatase-like, alpha/beta/alpha
 IPR017850  Alkaline-phosphatase-like, core domain superfamily
 IPR020436  Somatomedin B, chordata
 IPR020821  Extracellular Endonuclease, subunit A
 IPR029881  Ectonucleotide pyrophosphatase/phosphodiesterase family member 2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0006898 receptor-mediated endocytosis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0045765 regulation of angiogenesis IEA
 biological_processGO:0048709 oligodendrocyte differentiation IMP
 biological_processGO:0050848 regulation of calcium-mediated signaling IMP
 biological_processGO:0051216 cartilage development IMP
 biological_processGO:0060215 primitive hemopoiesis IMP
 biological_processGO:0060217 hemangioblast cell differentiation IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 biological_processGO:0090305 nucleic acid phosphodiester bond hydrolysis IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0004528 phosphodiesterase I activity IEA
 molecular_functionGO:0004551 nucleotide diphosphatase activity IEA
 molecular_functionGO:0004622 lysophospholipase activity IDA
 molecular_functionGO:0005044 scavenger receptor activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IDA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0030247 polysaccharide binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle morphology , abnormal
Kupffers vesicle cilium decreased volume , abnormal
Kupffers vesicle cilium decreased amount , abnormal
Kupffers vesicle deformed , abnormal
Kupffers vesicle decreased size , abnormal
Kupffers vesicle cell mislocalised , abnormal
Show

 ZFA:0000007 blood blood accumulation yolk , abnormal
Show

 ZFA:0000008 brain brain hemorrhagic , abnormal
Show

 ZFA:0000023 forerunner cell group forerunner cell group distributed , abnormal
Show

 ZFA:0000029 hindbrain hindbrain oligodendrocyte decreased amount , abnormal
hindbrain molecular quality , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000107 eye eye hemorrhagic , abnormal
Show

 ZFA:0000112 gut gut orientation whole organism left-right axis, abnormal
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 ZFA:0000737 cranium cranium malformed , abnormal
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 ZFA:0001061 intersegmental artery intersegmental artery attached to intersegmental artery , abnormal
intersegmental artery decreased length , abnormal
intersegmental artery attached to intersegmental vessel , abnormal
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 ZFA:0001114 head head circular , abnormal
head edematous , abnormal
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 ZFA:0001205 Meckel s cartilage Meckels cartilage deformed , abnormal
Meckels cartilage chondrocyte disorganized , abnormal
Meckels cartilage chondrocyte increased variability of size , abnormal
Show

 ZFA:0001400 ceratohyal cartilage ceratohyal cartilage deformed , abnormal
ceratohyal cartilage chondrocyte disorganized , abnormal
ceratohyal cartilage chondrocyte increased variability of size , abnormal
Show

 ZFA:0005024 trunk vasculature trunk vasculature malformed , abnormal
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 ZFA:0005025 dorsal longitudinal anastomotic vessel dorsal longitudinal anastomotic vessel aplastic , abnormal
Show

 ZFA:0009076 oligodendrocyte oligodendrocyte decreased amount , abnormal
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 ZFA:0009256 nucleate erythrocyte nucleate erythrocyte mislocalised , abnormal
nucleate erythrocyte decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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