ENSDARG00000013024


Danio rerio
activityerap1aaminopeptidasepeptidepeptidasemembraneantigenbindingmalaninehydrolaseendoplasmicreticulumpresentationmhcclassionleukotrienen-terminalerap-likec-terminaldomainaninopeptidasen-typeproteolysissignaltransductioncell-cellsignalingregulation

Features
Gene ID: ENSDARG00000013024
  
Biological name :erap1a
  
Synonyms : endoplasmic reticulum aminopeptidase 1a / erap1a
  
Possible biological names infered from orthology : endoplasmic reticulum aminopeptidase 1 / ERAP1 / Q9EQH2 / Q9NZ08
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 2899108
Gene end: 2921297
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000113611
NCBI entrez gene - 564068     See in Manteia.
RefSeq - XM_005155533
RefSeq - XM_687424
swissprot - E9QIR0
ZFIN ID - ZDB-GENE-091113-7
Ensembl - ENSDARG00000013024
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ERAP1ENSGALG00000014684Gallus gallus
 ERAP1ENSG00000164307Homo sapiens
 Erap1ENSMUSG00000021583Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
erap1b / endoplasmic reticulum aminopeptidase 1b / ERAP1* / Q9EQH2* / Q9NZ08* / endoplasmic reticulum aminopeptidase 1*ENSDARG0000002185968
erap2 / endoplasmic reticulum aminopeptidase 2 / Q6P179*ENSDARG0000009861849
lnpep / leucyl/cystinyl aminopeptidase / Q9UIQ6* / leucyl and cystinyl aminopeptidase*ENSDARG0000010039441
si:ch211-106j24.1 / ANPEP* / P15144* / P97449* / Aminopeptidase N * / alanyl aminopeptidase, membrane*ENSDARG0000003680931
enpep / glutamyl aminopeptidase / P16406* / Q07075*ENSDARG0000005706431
anpepb / alanyl (membrane) aminopeptidase b / ANPEP* / P97449* / P15144* / Aminopeptidase N * / alanyl aminopeptidase, membrane*ENSDARG0000010387831
npepps / aminopeptidase puromycin sensitive / P55786* / Q11011* / Puromycin-sensitive aminopeptidase *ENSDARG0000004494330
si:ch211-147g22.5 / ANPEP* / P15144* / P97449* / Aminopeptidase N * / alanyl aminopeptidase, membrane*ENSDARG0000009728530
anpepa / alanyl (membrane) aminopeptidase aENSDARG0000004108329
ANPEP / si:ch211-276a23.5 / P15144* / P97449* / Aminopeptidase N * / alanyl aminopeptidase, membrane*ENSDARG0000008970629
trhde.2 / trhde.1 / thyrotropin releasing hormone degrading enzyme, tandem duplicate 1 / TRHDE* / Q8K093* / Q9UKU6* / thyrotropin releasing hormone degrading enzyme* / Thyrotropin-releasing...ENSDARG0000010935829
trhde.2 / trhde.1 / thyrotropin releasing hormone degrading enzyme, tandem duplicate 2 / TRHDE* / Q8K093* / Q9UKU6* / thyrotropin releasing hormone degrading enzyme* / Thyrotropin-releasing...ENSDARG0000011183729


Protein motifs (from Interpro)
Interpro ID Name
 IPR001930  Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
 IPR014782  Peptidase M1, membrane alanine aminopeptidase, N-terminal
 IPR024571  ERAP1-like C-terminal domain
 IPR033520  Endoplasmic reticulum aninopeptidase 1
 IPR034016  Aminopeptidase N-type


Gene Ontology (GO)
nitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of biological qualitysystem processantigen processing and presentationcatabolic processcellular metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of biological qualitysystem processantigen processing and presentationcatabolic processcellular metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of biological qualitysystem processantigen processing and presentationcatabolic processcellular metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of biological qualitysystem processantigen processing and presentationcatabolic processcellular metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of biological qualitysystem processantigen processing and presentationcatabolic processcellular metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of biological qualitysystem processantigen processing and presentationcatabolic processcellular metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of biological qualitysystem processantigen processing and presentationcatabolic processcellular metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of biological qualitysystem processantigen processing and presentationcatabolic processcellular metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of biological qualitysystem processantigen processing and presentationcatabolic processcellular metabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusregulation of biological qualitysystem processantigen processing and presentationcatabolic processcellular metabolic processnitrogen componitrogen compound metabolic processprimary metaboprimary metabolic processorganic substaorganic substance metabolic processcell communicacell communicationcellular respocellular response to stimulusregulation of regulation of biological qualitysystem processsystem processantigen procesantigen processing and presentationcatabolic proccatabolic processcellular metabcellular metabolic process
catalytic activity, acting on a proteinhydrolase activityion bindingamide bindingcatalytic activity, acting on a proteinhydrolase activityion bindingamide bindingcatalytic activity, acting on a proteinhydrolase activityion bindingamide bindingcatalytic activity, acting on a proteinhydrolase activityion bindingamide bindingcatalytic activity, acting on a proteinhydrolase activityion bindingamide bindingcatalytic activity, acting on a proteinhydrolase activityion bindingamide bindingcatalytic activity, acting on a proteinhydrolase activityion bindingamide bindingcatalytic activity, acting on a proteinhydrolase activityion bindingamide bindingcatalytic activity, acting on a proteinhydrolase activityion bindingamide bindingcatalytic activity, acting on a proteinhydrolase activityion bindingamide bindingcatalytic activity, acting on a procatalytic activity, acting on a proteinhydrolase activityhydrolase activityion bindingion bindingamide bindingamide binding
cellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellmembraneorganellecellcellmembranemembraneorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IBA
 biological_processGO:0007165 signal transduction IBA
 biological_processGO:0007267 cell-cell signaling IBA
 biological_processGO:0008217 regulation of blood pressure IBA
 biological_processGO:0019885 antigen processing and presentation of endogenous peptide antigen via MHC class I IEA
 biological_processGO:0043171 peptide catabolic process IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IBA
 molecular_functionGO:0004177 aminopeptidase activity IEA
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008237 metallopeptidase activity IEA
 molecular_functionGO:0008270 zinc ion binding IBA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0042277 peptide binding IBA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0070006 metalloaminopeptidase activity IBA


Pathways (from Reactome)
Pathway description
Antigen Presentation: Folding, assembly and peptide loading of class I MHC


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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