ENSDARG00000016139


Danio rerio

Features
Gene ID: ENSDARG00000016139
  
Biological name :mkks
  
Synonyms : McKusick-Kaufman syndrome / mkks
  
Possible biological names infered from orthology : McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin / Q9JI70 / Q9NPJ1
  
Species: Danio rerio
  
Chr. number: 13
Strand: 1
Band:
Gene start: 35472803
Gene end: 35481843
  
Corresponding Affymetrix probe sets: Dr.9157.1.S1_at (Zebrafish Array)   NM_200165_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000024495
Ensembl peptide - ENSDARP00000151870
NCBI entrez gene - 393134     See in Manteia.
RefSeq - NM_200165
RefSeq - XM_021480541
RefSeq Peptide - NP_956459
swissprot - F1QCQ8
ZFIN ID - ZDB-GENE-040426-757
Ensembl - ENSDARG00000016139
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MKKSENSGALG00000009013Gallus gallus
 MKKSENSG00000125863Homo sapiens
 MkksENSMUSG00000027274Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR002423  Chaperonin Cpn60/TCP-1 family
 IPR027409  GroEL-like apical domain superfamily
 IPR027413  GroEL-like equatorial domain superfamily
 IPR028790  McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0006457 protein folding IEA
 biological_processGO:0006458 "de novo" protein folding IBA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007369 gastrulation IMP
 biological_processGO:0032402 melanosome transport IMP
 biological_processGO:0043010 camera-type eye development IGI
 biological_processGO:0046907 intracellular transport IMP
 biological_processGO:0048839 inner ear development IGI
 biological_processGO:0051877 pigment granule aggregation in cell center IMP
 biological_processGO:0060026 convergent extension IMP
 biological_processGO:0060027 convergent extension involved in gastrulation IMP
 biological_processGO:0060271 cilium assembly IMP
 biological_processGO:0061077 chaperone-mediated protein folding IBA
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0036064 ciliary basal body IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0044183 protein binding involved in protein folding IBA
 molecular_functionGO:0051082 unfolded protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle decreased size , abnormal
Kupffers vesicle cilium decreased length , abnormal
Show

 ZFA:0000133 neural rod neural rod increased width , abnormal
Show

 ZFA:0000135 notochord notochord increased width , abnormal
notochord kinked , abnormal
Show

 ZFA:0000155 somite somite increased width , abnormal
somite shape , abnormal
somite increased length , abnormal
somite amorphous , abnormal
somite antero-posteriorly flattened , abnormal
Show

 ZFA:0000529 kidney kidney edematous , abnormal
Show

 ZFA:0001094 whole organism whole organism anterior-posterior axis decreased length , abnormal
whole organism decreased length , abnormal
Show

 ZFA:0001117 post-vent region post-vent region morphology , abnormal
Show

 ZFA:0001211 presumptive rhombomere 5 presumptive rhombomere 5 decreased distance somite 1 , abnormal
Show

 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton decreased size , abnormal
Show

 ZFA:0001462 somite border somite border amorphous , abnormal
Show

 ZFA:0001580 neurocranium neurocranium decreased size , abnormal
Show

 ZFA:0001613 pharyngeal arch 3-7 pharyngeal arch 3-7 decreased size , abnormal
Show

 ZFA:0005290 proximal convoluted tubule proximal convoluted tubule decreased area , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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