ENSDARG00000019362


Danio rerio

Features
Gene ID: ENSDARG00000019362
  
Biological name :ptbp1a
  
Synonyms : polypyrimidine tract binding protein 1a / ptbp1a
  
Possible biological names infered from orthology : P26599 / polypyrimidine tract binding protein 1 / PTBP1
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 26288301
Gene end: 26300619
  
Corresponding Affymetrix probe sets: Dr.20803.1.S1_at (Zebrafish Array)   Dr.20803.2.S1_at (Zebrafish Array)   Dr.5460.1.A1_at (Zebrafish Array)   NM_001020477_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000011705
NCBI entrez gene - 323490     See in Manteia.
RefSeq - XM_021478816
RefSeq - NM_001020477
RefSeq Peptide - NP_001018313
swissprot - Q503D3
ZFIN ID - ZDB-GENE-050522-492
Ensembl - ENSDARG00000019362
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PTBP1ENSGALG00000001962Gallus gallus
 PTBP1ENSG00000011304Homo sapiens
 Ptbp1ENSMUSG00000006498Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ptbp1b / polypyrimidine tract binding protein 1b / PTBP1* / P26599* / polypyrimidine tract binding protein 1*ENSDARG0000003190784
ptbp3 / polypyrimidine tract binding protein 3 / O95758* / Q8BHD7*ENSDARG0000004375767
ptbp2b / polypyrimidine tract binding protein 2b / PTBP2* / Q91Z31* / Q9UKA9* / polypyrimidine tract binding protein 2*ENSDARG0000001590163
ptbp2a / polypyrimidine tract binding protein 2a / PTBP2* / Q91Z31* / Q9UKA9* / polypyrimidine tract binding protein 2*ENSDARG0000010194761
hnrnpl / heterogeneous nuclear ribonucleoprotein L / Q8R081* / P14866* / AC008982.1* / Heteroous nuclear ribonucleoprotein L *ENSDARG0000003532424
hnrnpl2 / heterogeneous nuclear ribonucleoprotein L2 / Q8R081* / P14866* / HNRNPL* / AC008982.1* / Heteroous nuclear ribonucleoprotein L * / heterogeneous nuclear ribonucleoprotein L*ENSDARG0000005930324
CABZ01100304.1 / Q8WVV9* / HNRNPLL* / heterogeneous nuclear ribonucleoprotein L like*ENSDARG0000011610110


Protein motifs (from Interpro)
Interpro ID Name
 IPR000504  RNA recognition motif domain
 IPR033110  ROD1, RNA recognition motif 4
 IPR034798  Polypyrimidine tract-binding protein1/2/3, RNA recognition motif 2
 IPR035000  PTBP1, RNA recognition motif 1
 IPR035001  PTBP1, RNA recognition motif 3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006397 mRNA processing IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0045595 regulation of cell differentiation IEA
 biological_processGO:0045746 negative regulation of Notch signaling pathway IMP
 biological_processGO:0060472 positive regulation of cortical granule exocytosis by positive regulation of cytosolic calcium ion concentration IMP
 biological_processGO:0060729 intestinal epithelial structure maintenance IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003676 nucleic acid binding IEA
 molecular_functionGO:0003723 RNA binding IEA


Pathways (from Reactome)
Pathway description
FGFR2 alternative splicing
mRNA Splicing - Major Pathway


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000084 yolk yolk opaque , abnormal
Show

 ZFA:0000093 blastomere blastomere microtubule disorganized , abnormal
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 ZFA:0000329 chorion chorion soft , abnormal
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 ZFA:0000541 marginal blastomere marginal blastomere microtubule disorganized , abnormal
marginal blastomere microtubule sparse , abnormal
Show

 ZFA:0001076 intestinal bulb intestinal bulb lacks parts or has fewer parts of type intestinal villus , abnormal
intestinal bulb muscle degenerate , abnormal
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 ZFA:0001094 whole organism whole organism wholly ventralized , abnormal
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 ZFA:0001175 blastodisc blastodisc decreased size , abnormal
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 ZFA:0001323 mid intestine mid intestine intestinal villus increased circumference , abnormal
mid intestine muscle degenerate , abnormal
Show

 ZFA:0005126 intestinal bulb epithelium intestinal bulb epithelium intestinal villus increased circumference , abnormal
intestinal bulb epithelium goblet cell decreased amount , abnormal
Show

 ZFA:0005127 mid intestine epithelium mid intestine epithelium goblet cell decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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