ENSDARG00000023002


Danio rerio

Features
Gene ID: ENSDARG00000023002
  
Biological name :dtl
  
Synonyms : denticleless E3 ubiquitin protein ligase homolog (Drosophila) / dtl / Q5RHI5
  
Possible biological names infered from orthology : denticleless E3 ubiquitin protein ligase homolog / Denticleless protein homolog / Q3TLR7 / Q9NZJ0
  
Species: Danio rerio
  
Chr. number: 20
Strand: 1
Band:
Gene start: 13141408
Gene end: 13174165
  
Corresponding Affymetrix probe sets: Dr.3526.1.S1_at (Zebrafish Array)   NM_173241_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000033992
NCBI entrez gene - 192314     See in Manteia.
RefSeq - XM_009294593
RefSeq - NM_173241
RefSeq Peptide - NP_775348
swissprot - Q5RHI5
ZFIN ID - ZDB-GENE-020419-34
Ensembl - ENSDARG00000023002
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 DTLENSGALG00000009837Gallus gallus
 DTLENSG00000143476Homo sapiens
 DtlENSMUSG00000037474Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001680  WD40 repeat
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017986  WD40-repeat-containing domain
 IPR019775  WD40 repeat, conserved site
 IPR020472  G-protein beta WD-40 repeat


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000209 protein polyubiquitination ISS
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006511 ubiquitin-dependent protein catabolic process ISS
 biological_processGO:0006513 protein monoubiquitination ISS
 biological_processGO:0006974 cellular response to DNA damage stimulus ISS
 biological_processGO:0007095 mitotic G2 DNA damage checkpoint IMP
 biological_processGO:0009411 response to UV ISS
 biological_processGO:0016567 protein ubiquitination IEA
 biological_processGO:0019985 translesion synthesis ISS
 biological_processGO:0051726 regulation of cell cycle ISS
 biological_processGO:0072425 signal transduction involved in G2 DNA damage checkpoint IMP
 biological_processGO:2000060 positive regulation of ubiquitin-dependent protein catabolic process IEA
 cellular_componentGO:0005634 nucleus ISS
 cellular_componentGO:0005694 chromosome IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome ISS
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0031464 Cul4A-RING E3 ubiquitin ligase complex ISS
 cellular_componentGO:0031465 Cul4B-RING E3 ubiquitin ligase complex ISS
 molecular_functionGO:0004842 ubiquitin-protein transferase activity ISS
 molecular_functionGO:0031490 chromatin DNA binding IEA


Pathways (from Reactome)
Pathway description
Recognition of DNA damage by PCNA-containing replication complex
Neddylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain necrotic , abnormal
Show

 ZFA:0000012 central nervous system central nervous system necrotic , abnormal
Show

 ZFA:0000098 proliferative region proliferative region spindle pole increased amount , abnormal
Show

 ZFA:0000106 extension extension decreased thickness , abnormal
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 ZFA:0001094 whole organism whole organism bent , abnormal
whole organism curved dorsal , abnormal
whole organism viability , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism necrotic , abnormal
Show

 ZFA:0001114 head head flat , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000060510 cul4b / cullin 4B / A2A432* / Q13620*  / complex
 ENSDARG00000038030 rbx1 / ring-box 1, E3 ubiquitin protein ligase / P62878* / P62877* / ring-box 1* / E3 ubiquitin-protein ligase RBX1 E3 ubiquitin-protein ligase RBX1, N-terminally processed*  / complex
 ENSDARG00000096578 cul4a / cullin 4A / Q13619* / Q3TCH7*  / complex
 ENSDARG00000003938 rpa1 / Q6NY74 / replication protein A1 / Q8VEE4* / P27694* / Replication protein A 70 kDa DNA-binding subunit *  / complex / reaction
 ENSDARG00000027689 pold1 / polymerase (DNA directed), delta 1, catalytic subunit / P28340* / P52431* / DNA polymerase delta 1, catalytic subunit*  / complex / reaction
 ENSDARG00000037188 rpa2 / replication protein A2 / RPA4* / Q13156* / P15927* / replication protein A4*  / complex / reaction
 ENSDARG00000054155 pcna / Q9PTP1 / proliferating cell nuclear antigen / P17918* / P12004* / Pcna-ps2*  / complex / reaction
 ENSDARG00000079632 si:dkey-28b4.7 / POLD4* / Q9CWP8* / Q9HCU8* / AP003419.1* / polymerase (DNA-directed), delta 4* / DNA polymerase delta 4, accessory subunit*  / complex / reaction






 

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