ENSDARG00000023963


Danio rerio

Features
Gene ID: ENSDARG00000023963
  
Biological name :tpm4a
  
Synonyms : tpm4a / tropomyosin 4a
  
Possible biological names infered from orthology : P67936 / Q6IRU2 / TPM4 / tropomyosin 4 / Tropomyosin alpha-4 chain
  
Species: Danio rerio
  
Chr. number: 22
Strand: -1
Band:
Gene start: 15577827
Gene end: 15602760
  
Corresponding Affymetrix probe sets: Dr.913.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000121408
Ensembl peptide - ENSDARP00000015843
Ensembl peptide - ENSDARP00000034733
Ensembl peptide - ENSDARP00000105889
Ensembl peptide - ENSDARP00000114668
NCBI entrez gene - 406437     See in Manteia.
RefSeq - NM_001024467
RefSeq Peptide - NP_001019638
swissprot - F1R412
swissprot - F1QKG7
swissprot - Q1LXM1
swissprot - Q1LXM2
swissprot - Q7T3F0
ZFIN ID - ZDB-GENE-040426-2185
Ensembl - ENSDARG00000023963
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TPM4ENSG00000167460Homo sapiens
 Tpm4ENSMUSG00000031799Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tpm3 / tropomyosin 3 / P21107* / P06753* / Tpm3-rs7* / tropomyosin 3, gamma*ENSDARG0000000516285
tpm2 / tropomyosin 2 (beta)ENSDARG0000010468283
tpma / P13104 / alpha-tropomyosin / TPM1* / P58771* / P09493* / tropomyosin 1* / tropomyosin 1, alpha*ENSDARG0000003368382
zgc:171719 / TPM1 (1 of many) / TPM1* / P09493* / tropomyosin 1*ENSDARG0000008740282
tpm4b / tropomyosin 4b / TPM4* / Q6IRU2* / P67936* / tropomyosin 4* / Tropomyosin alpha-4 chain *ENSDARG0000001912869


Protein motifs (from Interpro)
Interpro ID Name
 IPR000533  Tropomyosin


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007015 actin filament organization IBA
 biological_processGO:0055003 cardiac myofibril assembly IMP
 biological_processGO:0060047 heart contraction IMP
 biological_processGO:0060048 cardiac muscle contraction IMP
 cellular_componentGO:0005862 muscle thin filament tropomyosin IBA
 cellular_componentGO:0005884 actin filament IBA
 molecular_functionGO:0008307 structural constituent of muscle IBA
 molecular_functionGO:0051015 actin filament binding IBA


Pathways (from Reactome)
Pathway description
Striated Muscle Contraction
Smooth Muscle Contraction


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle myofibril disorganized , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000114 heart heart edematous , abnormal
heart decreased contractility , abnormal
heart contractility , abnormal
Show

 ZFA:0000154 sinus venosus sinus venosus increased accumulation blood , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell myofibril decreased amount , abnormal
cardiac muscle cell sarcomere disorganized , abnormal
cardiac muscle cell Z disc absent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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