ENSDARG00000024546


Danio rerio

Features
Gene ID: ENSDARG00000024546
  
Biological name :pla2g4aa
  
Synonyms : phospholipase A2, group IVAa (cytosolic, calcium-dependent) / pla2g4aa
  
Possible biological names infered from orthology : P47712 / P47713 / phospholipase A2 group IVA / phospholipase A2, group IVA (cytosolic, calcium-dependent) / PLA2G4A
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 20925899
Gene end: 20957362
  
Corresponding Affymetrix probe sets: Dr.20961.1.S1_at (Zebrafish Array)   NM_131295_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000090686
Ensembl peptide - ENSDARP00000143653
NCBI entrez gene - 30554     See in Manteia.
RefSeq - NM_131295
RefSeq Peptide - NP_571370
swissprot - F1QWF8
ZFIN ID - ZDB-GENE-990415-45
Ensembl - ENSDARG00000024546
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 P49147ENSGALG00000005065Gallus gallus
 P47712ENSG00000116711Homo sapiens
 P47713ENSMUSG00000056220Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pla2g4ab / phospholipase A2, group IVAb (cytosolic, calcium-dependent) / P47713* / P47712* / PLA2G4A* / phospholipase A2 group IVA* / phospholipase A2, group IVA (cytosolic, calcium-dependent)*ENSDARG0000001714175
pla2g4f.1 / phospholipase A2, group IVF, tandem duplicate 1 / Q68DD2* / Q50L41* / PLA2G4F* / phospholipase A2 group IVF* / Cytosolic phospholipase A2 zeta *ENSDARG0000005653526
pla2g4f.2 / phospholipase A2, group IVF, tandem duplicate 2 / Q68DD2* / Q50L41* / PLA2G4F* / phospholipase A2 group IVF* / Cytosolic phospholipase A2 zeta *ENSDARG0000007095325
zgc:101699 / Q9UP65* / PLA2G4C* / phospholipase A2 group IVC*ENSDARG0000003335517
si:ch73-55i23.1 / Q64GA5* / Q9UP65* / PLA2G4C* / phospholipase A2 group IVC* / Cytosolic phospholipase A2 gamma *ENSDARG0000004209017
si:ch73-55i23.1 / Q9UP65* / PLA2G4C* / phospholipase A2 group IVC*ENSDARG0000004598217
LO018584.1 / Q9UP65* / PLA2G4C* / phospholipase A2 group IVC*ENSDARG0000010172116


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR002642  Lysophospholipase, catalytic domain
 IPR016035  Acyl transferase/acyl hydrolase/lysophospholipase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0009395 phospholipid catabolic process IEA
 biological_processGO:0016042 lipid catabolic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0004620 phospholipase activity IEA
 molecular_functionGO:0004623 phospholipase A2 activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA
 molecular_functionGO:0102567 phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) IEA
 molecular_functionGO:0102568 phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine) IEA


Pathways (from Reactome)
Pathway description
phospho-PLA2 pathway
Acyl chain remodelling of PC
Acyl chain remodeling of CL
Acyl chain remodelling of PS
Acyl chain remodelling of PE
Acyl chain remodelling of PI
Acyl chain remodelling of PG
Hydrolysis of LPC
Synthesis of PA
Arachidonic acid metabolism
ADP signalling through P2Y purinoceptor 1
Platelet sensitization by LDL
COPI-independent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
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 ZFA:0000106 extension extension decreased length , abnormal
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 ZFA:0001094 whole organism whole organism anterior-posterior axis decreased length , abnormal
whole organism anterior-posterior axis length , ameliorated
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 ZFA:0001114 head head decreased size , abnormal
head size , ameliorated
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 ZFA:0001617 otolith otolith decreased size , abnormal
otolith incomplete structure , abnormal
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 ZFA:0009309 leukocyte leukocyte decreased velocity , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000028721 mapk14b / mitogen-activated protein kinase 14b / Q16539* / MAPK14* / P47811* / mitogen-activated protein kinase 14*  / reaction
 ENSDARG00000027552 mapk1 / mitogen-activated protein kinase 1 / P28482* / P63085* / Mus musculus mitogen-activated protein kinase 1 (Mapk1), transcript variant 3, mRNA.*  / reaction
 ENSDARG00000000857 Q9DGE2 / mapk14a / mitogen-activated protein kinase 14a / P47811* / Q16539* / MAPK14* / mitogen-activated protein kinase 14*  / reaction






 

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