ENSDARG00000027099


Danio rerio

Features
Gene ID: ENSDARG00000027099
  
Biological name :psmc4
  
Synonyms : proteasome 26S subunit, ATPase 4 / psmc4
  
Possible biological names infered from orthology : 26S proteasome regulatory subunit 6B / P43686 / P54775
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 41794715
Gene end: 41805240
  
Corresponding Affymetrix probe sets: Dr.3054.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000034904
Ensembl peptide - ENSDARP00000121136
NCBI entrez gene - 326884     See in Manteia.
swissprot - B0R1D0
swissprot - F1R5E3
ZFIN ID - ZDB-GENE-030131-5083
Ensembl - ENSDARG00000027099
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PSMC4ENSG00000013275Homo sapiens
 Psmc4ENSMUSG00000030603Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR003960  ATPase, AAA-type, conserved site
 IPR005937  26S proteasome regulatory subunit P45-like
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR035256  26S Proteasome regulatory subunit 6B


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030163 protein catabolic process IEA
 biological_processGO:0030433 ubiquitin-dependent ERAD pathway IBA
 biological_processGO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly IBA
 biological_processGO:1901800 positive regulation of proteasomal protein catabolic process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0008540 proteasome regulatory particle, base subcomplex IBA
 cellular_componentGO:0031595 nuclear proteasome complex IBA
 cellular_componentGO:0031597 cytosolic proteasome complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0017025 TBP-class protein binding IBA
 molecular_functionGO:0036402 proteasome-activating ATPase activity IBA


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
FCERI mediated NF-kB activation
The role of GTSE1 in G2/M progression after G2 checkpoint
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Antigen processing: Ubiquitination & Proteasome degradation
Regulation of RUNX2 expression and activity
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Degradation of GLI1 by the proteasome
SCF(Skp2)-mediated degradation of p27/p21
Regulation of ornithine decarboxylase (ODC)
Regulation of RAS by GAPs
Asymmetric localization of PCP proteins
Autodegradation of Cdh1 by Cdh1:APC/C
Degradation of beta-catenin by the destruction complex
Autodegradation of the E3 ubiquitin ligase COP1
APC/C:Cdc20 mediated degradation of Securin
G2/M Checkpoints
CDT1 association with the CDC6:ORC:origin complex
Dectin-1 mediated noncanonical NF-kB signaling
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Activation of NF-kappaB in B cells
AUF1 (hnRNP D0) binds and destabilizes mRNA
CDK-mediated phosphorylation and removal of Cdc6
CLEC7A (Dectin-1) signaling
Cross-presentation of soluble exogenous antigens (endosomes)
Degradation of AXIN
Degradation of DVL
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Downstream TCR signaling
Hedgehog on state
Interleukin-1 signaling
MAPK6/MAPK4 signaling
Neddylation
NIK-->noncanonical NF-kB signaling
Orc1 removal from chromatin
Regulation of PTEN stability and activity
Regulation of RUNX3 expression and activity
Separation of Sister Chromatids
TNFR2 non-canonical NF-kB pathway
UCH proteinases
Ub-specific processing proteases
Ubiquitin-dependent degradation of Cyclin D1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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