ENSDARG00000030759


Danio rerio

Features
Gene ID: ENSDARG00000030759
  
Biological name :melk
  
Synonyms : F1QGZ6 / maternal embryonic leucine zipper kinase / melk
  
Possible biological names infered from orthology : Q14680 / Q61846
  
Species: Danio rerio
  
Chr. number: 1
Strand: -1
Band:
Gene start: 21861387
Gene end: 21881818
  
Corresponding Affymetrix probe sets: Dr.18106.1.S1_at (Zebrafish Array)   Dr.18106.2.A1_at (Zebrafish Array)   NM_206888_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000047727
NCBI entrez gene - 30724     See in Manteia.
RefSeq - NM_206888
RefSeq Peptide - NP_996771
swissprot - F1QGZ6
ZFIN ID - ZDB-GENE-990603-5
Ensembl - ENSDARG00000030759
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MELKENSGALG00000016438Gallus gallus
 MELKENSG00000165304Homo sapiens
 MelkENSMUSG00000035683Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hunk / hormonally up-regulated Neu-associated kinase / O88866* / P57058* / Hormonally up-regulated neu tumor-associated kinase *ENSDARG0000009131719
si:ch211-197l9.5ENSDARG0000008667917


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001772  Kinase associated domain 1 (KA1)
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR028375  KA1 domain/Ssp2, C-terminal
 IPR034673  Maternal embryonic leucine zipper kinase, catalytic domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006915 apoptotic process ISS
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0008283 cell proliferation ISS
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0018108 peptidyl-tyrosine phosphorylation IBA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0043065 positive regulation of apoptotic process ISS
 biological_processGO:0046777 protein autophosphorylation ISS
 biological_processGO:0048821 erythrocyte development IMP
 biological_processGO:0061351 neural precursor cell proliferation ISS
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005938 cell cortex ISS
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity ISS
 molecular_functionGO:0004715 non-membrane spanning protein tyrosine kinase activity ISS
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000007 blood blood hemoglobin complex absent , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0000445 optic tectum optic tectum increased size , abnormal
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 ZFA:0001094 whole organism whole organism has fewer parts of type nucleate erythrocyte , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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