ENSDARG00000031246


Danio rerio
signalinghbegfberbbeventsgrowthfactorreceptorpiepidermalkegf-likeregulationcellactivitymembraneshcactivatesaktptkdomainconservedsiteligandpathwayproliferationheartcontractionextracellularspaceintegralcomponent

Features
Gene ID: ENSDARG00000031246
  
Biological name :hbegfb
  
Synonyms : hbegfb / heparin-binding EGF-like growth factor b
  
Possible biological names infered from orthology : HBEGF / heparin binding EGF like growth factor / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like growth factor / Q06186 / Q99075
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 30161295
Gene end: 30168949
  
Corresponding Affymetrix probe sets: Dr.15448.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000152981
Ensembl peptide - ENSDARP00000109312
Ensembl peptide - ENSDARP00000109242
NCBI entrez gene - 407664     See in Manteia.
RefSeq - NM_001100401
RefSeq - XM_005161297
RefSeq Peptide - NP_001093871
swissprot - F1QKE6
swissprot - F1QEL2
ZFIN ID - ZDB-GENE-070820-6
Ensembl - ENSDARG00000031246
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HBEGFENSGALG00000000949Gallus gallus
 HBEGFENSG00000113070Homo sapiens
 HbegfENSMUSG00000024486Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
hbegfa / heparin-binding EGF-like growth factor a / HBEGF* / Q06186* / Q99075* / heparin binding EGF like growth factor* / Proheparin-binding EGF-like growth factor Heparin-binding EGF-like...ENSDARG0000007512136
areg / amphiregulin / Mcub* / P15514* / P31955*ENSDARG0000007685317


Protein motifs (from Interpro)
Interpro ID Name
 IPR000742  EGF-like domain
 IPR013032  EGF-like, conserved site
 IPR015497  Epidermal growth factor receptor ligand


Gene Ontology (GO)
cell communicationcellular response to stimulusregulation of molecular functionsystem processcell communicationcellular response to stimulusregulation of molecular functionsystem processcell communicationcellular response to stimulusregulation of molecular functionsystem processcell communicationcellular response to stimulusregulation of molecular functionsystem processcell communicationcellular response to stimulusregulation of molecular functionsystem processcell communicationcellular response to stimulusregulation of molecular functionsystem processcell communicationcellular response to stimulusregulation of molecular functionsystem processcell communicationcellular response to stimulusregulation of molecular functionsystem processcell communicationcellular response to stimulusregulation of molecular functionsystem processcell communicationcellular response to stimulusregulation of molecular functionsystem processcell communicationcell communicationcellular response to stimuluscellular response to stimulusregulation of molecular functionregulation of molecular functionsystem processsystem process
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
extracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionmembraneextracellular regionextracellular regionmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0007173 epidermal growth factor receptor signaling pathway IBA
 biological_processGO:0008284 positive regulation of cell proliferation IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0060047 heart contraction IMP
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005154 epidermal growth factor receptor binding IBA
 molecular_functionGO:0008083 growth factor activity IBA


Pathways (from Reactome)
Pathway description
Signaling by ERBB2
Signaling by ERBB4
SHC1 events in ERBB2 signaling
PI3K events in ERBB4 signaling
SHC1 events in ERBB4 signaling
PIP3 activates AKT signaling
GRB2 events in ERBB2 signaling
PI3K events in ERBB2 signaling
EGFR Transactivation by Gastrin
RAF/MAP kinase cascade
ERBB2 Regulates Cell Motility
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
ERBB2 Activates PTK6 Signaling
PTK6 promotes HIF1A stabilization
Downregulation of ERBB2 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle increased size , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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