ENSDARG00000032565


Danio rerio

Features
Gene ID: ENSDARG00000032565
  
Biological name :cacng2a
  
Synonyms : cacng2a / calcium channel, voltage-dependent, gamma subunit 2a
  
Possible biological names infered from orthology : CACNG2 / calcium voltage-gated channel auxiliary subunit gamma 2 / O88602 / Q9Y698 / Voltage-dependent calcium channel gamma-2 subunit
  
Species: Danio rerio
  
Chr. number: 3
Strand: 1
Band:
Gene start: 29714775
Gene end: 29845175
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000041387
NCBI entrez gene - 393614     See in Manteia.
RefSeq - NM_200641
RefSeq Peptide - NP_956935
swissprot - Q6PFS3
ZFIN ID - ZDB-GENE-040426-1401
Ensembl - ENSDARG00000032565
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CACNG2ENSGALG00000031977Gallus gallus
 CACNG2ENSG00000166862Homo sapiens
 Cacng2ENSMUSG00000019146Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cacng3b / calcium channel, voltage-dependent, gamma subunit 3b / CACNG3* / O60359* / Q9JJV5* / Voltage-dependent calcium channel gamma-3 subunit * / calcium voltage-gated channel auxiliary ...ENSDARG0000007640173
cacng8b / calcium channel, voltage-dependent, gamma subunit 8b / CACNG8* / Q8WXS5* / voltage-dependent calcium channel gamma-8 subunit * / calcium voltage-gated channel auxiliary subunit gamma 8*ENSDARG0000007062660
cacng4b / calcium channel, voltage-dependent, gamma subunit 4b / CACNG4* / Q9UBN1* / calcium voltage-gated channel auxiliary subunit gamma 4*ENSDARG0000007466960
cacng8a / calcium channel, voltage-dependent, gamma subunit 8a / CACNG8* / Q8WXS5* / voltage-dependent calcium channel gamma-8 subunit * / calcium voltage-gated channel auxiliary subunit gamma 8*ENSDARG0000002045059
cacng3a / calcium channel, voltage-dependent, gamma subunit 3a / CACNG3* / O60359* / Q9JJV5* / Voltage-dependent calcium channel gamma-3 subunit * / calcium voltage-gated channel auxiliary ...ENSDARG0000005846059
cacng4a / calcium channel, voltage-dependent, gamma subunit 4a / CACNG4* / Q9UBN1* / calcium voltage-gated channel auxiliary subunit gamma 4*ENSDARG0000011554052
cacng5a / calcium channel, voltage-dependent, gamma subunit 5a / CACNG5* / Q9UF02* / calcium voltage-gated channel auxiliary subunit gamma 5*ENSDARG0000000332626
cacng7a / calcium channel, voltage-dependent, gamma subunit 7a / CACNG7* / P62955* / P62956* / Voltage-dependent calcium channel gamma-7 subunit * / calcium voltage-gated channel auxiliary ...ENSDARG0000006300626
cacng7b / calcium channel, voltage-dependent, gamma subunit 7b / CACNG7* / P62955* / P62956* / Voltage-dependent calcium channel gamma-7 subunit * / calcium voltage-gated channel auxiliary ...ENSDARG0000007062426
cacng5a / cacng5b / calcium channel, voltage-dependent, gamma subunit 5b / CACNG5* / Q9UF02* / Q8VHW4* / Voltage-dependent calcium channel gamma-5 subunit * / calcium voltage-gated channel ...ENSDARG0000003924025


Protein motifs (from Interpro)
Interpro ID Name
 IPR004031  PMP-22/EMP/MP20/Claudin superfamily
 IPR005422  Voltage-dependent calcium channel, gamma-2 subunit
 IPR008368  Voltage-dependent calcium channel, gamma subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0019226 transmission of nerve impulse IBA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0070588 calcium ion transmembrane transport IBA
 biological_processGO:0098990 AMPA selective glutamate receptor signaling pathway IMP
 biological_processGO:2000311 regulation of AMPA receptor activity IBA
 cellular_componentGO:0005891 voltage-gated calcium channel complex IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032281 AMPA glutamate receptor complex IBA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IBA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0016247 channel regulator activity IBA


Pathways (from Reactome)
Pathway description
Presynaptic depolarization and calcium channel opening
Phase 0 - rapid depolarisation
Phase 2 - plateau phase


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000029 hindbrain hindbrain decreased amount , abnormal
hindbrain AMPA glutamate receptor clustering decreased occurrence , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0009149 Mauthner neuron Mauthner neuron has fewer parts of type Mauthner neuron AMPA glutamate receptor complex, abnormal
Mauthner neuron AMPA selective glutamate receptor signaling pathway decreased rate , abnormal
Mauthner neuron AMPA selective glutamate receptor signaling pathway decreased magnitude , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000060532 adam22 / ADAM metallopeptidase domain 22 / Q9P0K1* / Q9R1V6* / Disintegrin and metalloproteinase domain-containing protein 22 *  / complex






 

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