ENSDARG00000032619


Danio rerio

Features
Gene ID: ENSDARG00000032619
  
Biological name :tob1a
  
Synonyms : tob1a / transducer of ERBB2, 1a
  
Possible biological names infered from orthology : P50616 / Protein Tob1 / Q61471 / TOB1 / transducer of ERBB2, 1
  
Species: Danio rerio
  
Chr. number: 3
Strand: -1
Band:
Gene start: 18185616
Gene end: 18189283
  
Corresponding Affymetrix probe sets: Dr.4590.1.A1_at (Zebrafish Array)   NM_198363_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000049239
NCBI entrez gene - 386629     See in Manteia.
RefSeq - NM_198363
RefSeq Peptide - NP_938177
swissprot - Q7SZR1
ZFIN ID - ZDB-GENE-031030-4
Ensembl - ENSDARG00000032619
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TOB1ENSGALG00000007364Gallus gallus
 TOB1ENSG00000141232Homo sapiens
 Tob1ENSMUSG00000037573Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tob1b / transducer of ERBB2, 1b / TOB1* / Q61471* / P50616* / Protein Tob1 * / transducer of ERBB2, 1*ENSDARG0000002137284
btg1 / B-cell translocation gene 1, anti-proliferative / P62324* / P62325* / Btg1-ps2* / Btg1-ps1* / Protein BTG1 * / BTG anti-proliferation factor 1* / B cell translocation gene 1, anti-pr...ENSDARG0000002724920
btg3 / B-cell translocation gene 3 / Q14201* / Gm7334* / P50615* / Protein BTG3 * / predicted gene 7334* / BTG anti-proliferation factor 3*ENSDARG0000006906519
si:dkey-42i9.4ENSDARG0000000804918
btg4 / B-cell translocation gene 4 / O70552* / Q9NY30* / Protein BTG4 * / BTG anti-proliferation factor 4*ENSDARG0000003517118
btg2 / B-cell translocation gene 2 / P78543* / BTG anti-proliferation factor 2*ENSDARG0000002029817
si:dkey-79d12.5ENSDARG0000004028416


Protein motifs (from Interpro)
Interpro ID Name
 IPR002087  Anti-proliferative protein
 IPR015676  Tob1/2
 IPR015677  Tob1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation IEA
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0016055 Wnt signaling pathway IGI
 biological_processGO:0030509 BMP signaling pathway IDA
 biological_processGO:0060070 canonical Wnt signaling pathway IGI
 biological_processGO:1903507 negative regulation of nucleic acid-templated transcription IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0003714 transcription corepressor activity IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000077 tail bud tail bud umbonate , abnormal
Show

 ZFA:0001069 ventral fin fold ventral fin fold decreased size , abnormal
Show

 ZFA:0001094 whole organism whole organism wholly dorsalized , abnormal
Show

 ZFA:0001117 post-vent region post-vent region decreased length , abnormal
post-vent region malformed , abnormal
post-vent region kinked , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr