ENSDARG00000032801


Danio rerio

Features
Gene ID: ENSDARG00000032801
  
Biological name :grk5
  
Synonyms : G protein-coupled receptor kinase 5 / grk5
  
Possible biological names infered from orthology : P34947 / Q8VEB1
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 2715548
Gene end: 2755378
  
Corresponding Affymetrix probe sets: Dr.18531.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000104968
Ensembl peptide - ENSDARP00000104746
NCBI entrez gene - 560806     See in Manteia.
RefSeq - NM_001173503
RefSeq Peptide - NP_001166974
swissprot - F1RAR9
swissprot - F1R0T6
ZFIN ID - ZDB-GENE-091204-274
Ensembl - ENSDARG00000032801
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GRK5ENSGALG00000009403Gallus gallus
 GRK5ENSG00000198873Homo sapiens
 Grk5ENSMUSG00000003228Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
grk5l / G protein-coupled receptor kinase 5 like / GRK5* / P34947* / Q8VEB1* / G protein-coupled receptor kinase 5*ENSDARG0000007881557
grk4 / G protein-coupled receptor kinase 4 / O70291* / P32298*ENSDARG0000007044853
grk6 / G protein-coupled receptor kinase 6 / P43250*ENSDARG0000003215752
grk1a / G protein-coupled receptor kinase 1 a / GRK1* / Q15835* / G protein-coupled receptor kinase 1*ENSDARG0000005880338
grk1b / G protein-coupled receptor kinase 1 bENSDARG0000010468538
grk7a / Q49HM9 / G protein-coupled receptor kinase 7a / GRK7* / Q8WTQ7* / G protein-coupled receptor kinase 7*ENSDARG0000002060237
grk7b / Q1XHL7 / G protein-coupled receptor kinase 7b / GRK7* / Q8WTQ7* / G protein-coupled receptor kinase 7*ENSDARG0000005553437
grk3 / G protein-coupled receptor kinase 3 / P35626* / Q3UYH7* / Beta-adrenergic receptor kinase 2 *ENSDARG0000010409431


Protein motifs (from Interpro)
Interpro ID Name
 IPR000239  GPCR kinase
 IPR000719  Protein kinase domain
 IPR000961  AGC-kinase, C-terminal
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR016137  RGS domain
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007507 heart development IMP
 biological_processGO:0008016 regulation of heart contraction IMP
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0030177 positive regulation of Wnt signaling pathway IMP
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004703 G-protein coupled receptor kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain morphology , abnormal
Show

 ZFA:0000028 heart primordium heart primordium decreased size , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000114 heart heart malformed , abnormal
heart decreased size , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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