ENSDARG00000034409


Danio rerio

Features
Gene ID: ENSDARG00000034409
  
Biological name :pik3r3b
  
Synonyms : phosphoinositide-3-kinase, regulatory subunit 3b (gamma) / pik3r3b
  
Possible biological names infered from orthology : AL358075.4 / AL670603.1 / Phosphatidylinositol 3-kinase regulatory subunit gamma / phosphoinositide-3-kinase regulatory subunit 3 / PIK3R3 / Q64143 / Q92569
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 33537267
Gene end: 33558977
  
Corresponding Affymetrix probe sets: Dr.24191.1.S1_at (Zebrafish Array)   Dr.5428.2.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000040333
NCBI entrez gene - 100000252     See in Manteia.
RefSeq - NM_201143
RefSeq Peptide - NP_957437
swissprot - Q7ZVW3
ZFIN ID - ZDB-GENE-040426-743
Ensembl - ENSDARG00000034409
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000010335Gallus gallus
 AL358075.4ENSG00000278139Homo sapiens
 PIK3R3ENSG00000117461Homo sapiens
 AL670603.1ENSMUSG00000111410Mus musculus
 Pik3r3ENSMUSG00000028698Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pik3r1 / phosphoinositide-3-kinase, regulatory subunit 1 (alpha) / P26450* / P27986* / phosphoinositide-3-kinase regulatory subunit 1*ENSDARG0000003852472
pik3r2 / phosphoinositide-3-kinase, regulatory subunit 2 (beta) / O00459* / O08908* / AC007192.1* / phosphoinositide-3-kinase regulatory subunit 2* / Phosphatidylinositol 3-kinase regulator...ENSDARG0000001806067
pik3r3a / phosphoinositide-3-kinase, regulatory subunit 3a (gamma)ENSDARG0000010303837


Protein motifs (from Interpro)
Interpro ID Name
 IPR000980  SH2 domain
 IPR032498  PI3K p85 subunit, inter-SH2 domain
 IPR035020  PI3K p85 subunit, C-terminal SH2 domain
 IPR035022  PI3K p85 subunit, N-terminal SH2 domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0008286 insulin receptor signaling pathway IBA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IBA
 biological_processGO:0046854 phosphatidylinositol phosphorylation IBA
 cellular_componentGO:0005942 phosphatidylinositol 3-kinase complex IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0035014 phosphatidylinositol 3-kinase regulator activity IEA
 molecular_functionGO:0046935 1-phosphatidylinositol-3-kinase regulator activity IBA


Pathways (from Reactome)
Pathway description
GPVI-mediated activation cascade
PIP3 activates AKT signaling
Interleukin-7 signaling
Signaling by SCF-KIT
Synthesis of PIPs at the plasma membrane
G alpha (q) signalling events
G alpha (12/13) signalling events
PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
RET signaling
Interleukin receptor SHC signaling
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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