ENSDARG00000035390


Danio rerio
proteintnpo1nucleusimportnucleartransportbindingcellimportin-betan-terminaldomainarmadillo-likehelicalarmadillo-typefoldtranslocationnls-bearingribosomalintracellularcytoplasmmembraneperipherylocalizationsequencerangtpasetransporteractivityintraflagellaradaxialsomite

Features
Gene ID: ENSDARG00000035390
  
Biological name :tnpo1
  
Synonyms : tnpo1 / transportin 1
  
Possible biological names infered from orthology : Q8BFY9 / Q92973
  
Species: Danio rerio
  
Chr. number: 5
Strand: -1
Band:
Gene start: 35202063
Gene end: 35252761
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000051277
NCBI entrez gene - 562607     See in Manteia.
RefSeq - XM_021471632
RefSeq - XM_685987
swissprot - F1RDR1
ZFIN ID - ZDB-GENE-080819-1
Ensembl - ENSDARG00000035390
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 TNPO1ENSGALG00000015014Gallus gallus
 TNPO1ENSG00000083312Homo sapiens
 Tnpo1ENSMUSG00000009470Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tnpo2 / transportin 2 (importin 3, karyopherin beta 2b) / O14787* / Q99LG2* / transportin 2*ENSDARG0000003823984
LO017798.1 / TNPO2* / O14787* / transportin 2*ENSDARG0000004288747
LO017722.1 / TNPO2* / O14787* / transportin 2*ENSDARG0000011329610


Protein motifs (from Interpro)
Interpro ID Name
 IPR001494  Importin-beta, N-terminal domain
 IPR011989  Armadillo-like helical
 IPR016024  Armadillo-type fold


Gene Ontology (GO)
macromolecule localizationestablishment of localizationcellular localizationmacromolecule localizationestablishment of localizationcellular localizationmacromolecule localizationestablishment of localizationcellular localizationmacromolecule localizationestablishment of localizationcellular localizationmacromolecule localizationestablishment of localizationcellular localizationmacromolecule localizationestablishment of localizationcellular localizationmacromolecule localizationestablishment of localizationcellular localizationmacromolecule localizationestablishment of localizationcellular localizationmacromolecule localizationestablishment of localizationcellular localizationmacromolecule localizationestablishment of localizationcellular localizationmacromolecule localizationmacromolecule localizationestablishment of localizationestablishment of localizationcellular localizationcellular localization
amide bindingprotein bindingprotein transporter activityamide bindingprotein bindingprotein transporter activityamide bindingprotein bindingprotein transporter activityamide bindingprotein bindingprotein transporter activityamide bindingprotein bindingprotein transporter activityamide bindingprotein bindingprotein transporter activityamide bindingprotein bindingprotein transporter activityamide bindingprotein bindingprotein transporter activityamide bindingprotein bindingprotein transporter activityamide bindingprotein bindingprotein transporter activityamide bindingamide bindingprotein bindingprotein bindingprotein transporter activityprotein transporter activity
cellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellorganellemembranemembrane-enclosed lumencellcellorganelleorganellemembranemembranemembrane-enclosed lumenmembrane-enclosed lumen
TypeGO IDTermEv.Code
 biological_processGO:0000060 protein import into nucleus, translocation IBA
 biological_processGO:0006607 NLS-bearing protein import into nucleus IBA
 biological_processGO:0006610 ribosomal protein import into nucleus IBA
 biological_processGO:0006886 intracellular protein transport IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031965 nuclear membrane IBA
 cellular_componentGO:0034399 nuclear periphery IBA
 molecular_functionGO:0008139 nuclear localization sequence binding IBA
 molecular_functionGO:0008536 Ran GTPase binding IEA
 molecular_functionGO:0008565 protein transporter activity IBA


Pathways (from Reactome)
Pathway description
Intraflagellar transport


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000003 adaxial cell adaxial cell decreased amount , abnormal
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 ZFA:0000155 somite somite U-shaped , abnormal
somite decreased amount , abnormal
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 ZFA:0001094 whole organism whole organism decreased amount , abnormal
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 ZFA:0009116 slow muscle cell slow muscle cell morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000055238 kif17 / kinesin family member 17 / Q99PW8* / Q9P2E2* / Kinesin-like protein KIF17 *  / complex / reaction






 

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