ENSDARG00000035655


Danio rerio
sisterrad21bchromatidcohesionradrec-likeproteinrepairnuclearcohesinchromatinc-terminaleukaryoticn-terminalarsr-likehelix-turn-helixdomaindouble-strandbreakchromosomecomplexbindingseparationchromatidsestablishmentloadingontoresolutionsumoylationdna

Features
Gene ID: ENSDARG00000035655
  
Biological name :rad21b
  
Synonyms : rad21b / RAD21 cohesin complex component b
  
Possible biological names infered from orthology : Double-strand-break repair / O60216 / Q61550 / RAD21 / RAD21 cohesin complex component
  
Species: Danio rerio
  
Chr. number: 19
Strand: -1
Band:
Gene start: 44068250
Gene end: 44091405
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000122549
Ensembl peptide - ENSDARP00000156625
NCBI entrez gene - 566831     See in Manteia.
RefSeq - NM_001045120
RefSeq Peptide - NP_001038585
swissprot - Q1L8E1
ZFIN ID - ZDB-GENE-060503-223
Ensembl - ENSDARG00000035655
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAD21ENSGALG00000029523Gallus gallus
 RAD21ENSG00000164754Homo sapiens
 Rad21ENSMUSG00000022314Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rad21a / RAD21 cohesin complex component a / RAD21* / Q61550* / O60216* / Double-strand-break repair * / RAD21 cohesin complex component*ENSDARG0000000609281
rad21l1 / RAD21 cohesin complex component like 1ENSDARG0000002249335


Protein motifs (from Interpro)
Interpro ID Name
 IPR006909  Rad21/Rec8-like protein, C-terminal, eukaryotic
 IPR006910  Rad21/Rec8-like protein, N-terminal
 IPR011991  ArsR-like helix-turn-helix domain


Gene Ontology (GO)
nitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcell cyclechromosome segregationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcell cyclechromosome segregationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcell cyclechromosome segregationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcell cyclechromosome segregationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcell cyclechromosome segregationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcell cyclechromosome segregationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcell cyclechromosome segregationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcell cyclechromosome segregationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcell cyclechromosome segregationnitrogen compound metabolic processresponse to stresscellular metabolic processprimary metabolic processorganic substance metabolic processcellular response to stimuluscellular component organizationcell cyclechromosome segregationnitrogen compounitrogen compound metabolic processresponse to strresponse to stresscellular metabocellular metabolic processprimary metabolprimary metabolic processorganic substanorganic substance metabolic processcellular responcellular response to stimuluscellular componcellular component organizationcell cyclecell cyclechromosome segrchromosome segregation
chromatin bindingchromatin bindingchromatin bindingchromatin bindingchromatin bindingchromatin bindingchromatin bindingchromatin bindingchromatin bindingchromatin bindingchromatin bindingchromatin binding
cellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellorganellemembrane-enclosed lumenprotein-containing complexcellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenprotein-containing complexprotein-containing complex
TypeGO IDTermEv.Code
 biological_processGO:0006302 double-strand break repair IBA
 biological_processGO:0007062 sister chromatid cohesion IBA
 cellular_componentGO:0000228 nuclear chromosome IEA
 cellular_componentGO:0000798 nuclear cohesin complex IBA
 molecular_functionGO:0003682 chromatin binding IBA


Pathways (from Reactome)
Pathway description
Separation of Sister Chromatids
Establishment of Sister Chromatid Cohesion
Cohesin Loading onto Chromatin
Resolution of Sister Chromatid Cohesion
SUMOylation of DNA damage response and repair proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000044144 wapla / WAPL cohesin release factor a / WAPL* / Q7Z5K2* / Q65Z40* / WAPL cohesin release factor*  / reaction
 ENSDARG00000055022 pds5a / PDS5 cohesin associated factor A / Q29RF7*  / reaction
 ENSDARG00000044267 sumo1 / Q7SZR5 / small ubiquitin-like modifier 1 / P63166* / P63165* / Small ubiquitin-related modifier 1 *  / complex
 ENSDARG00000098897 pds5b / PDS5 cohesin associated factor B / Q4VA53* / Q9NTI5* / Mus musculus PDS5 cohesin associated factor B (Pds5b), transcript variant 2, mRNA.*  / reaction






 

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