ENSDARG00000038205


Danio rerio

Features
Gene ID: ENSDARG00000038205
  
Biological name :her2
  
Synonyms : hairy-related 2 / her2
  
Possible biological names infered from orthology : HES5 / hes family bHLH transcription factor 5 / P70120 / Q5TA89 / Transcription factor HES-5
  
Species: Danio rerio
  
Chr. number: 11
Strand: -1
Band:
Gene start: 41966117
Gene end: 41966854
  
Corresponding Affymetrix probe sets: Dr.1460.1.S1_at (Zebrafish Array)   NM_131089_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000055708
NCBI entrez gene - 30300     See in Manteia.
RefSeq - NM_131089
RefSeq Peptide - NP_571164
swissprot - F6PBN7
swissprot - Q90464
ZFIN ID - ZDB-GENE-980526-274
Ensembl - ENSDARG00000038205
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000027002Gallus gallus
 hairy and enhancer of split 5-like ENSGALG00000001136Gallus gallus
 HES5ENSGALG00000001141Gallus gallus
 HES5ENSG00000197921Homo sapiens
 Hes5ENSMUSG00000048001Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
her12 / hairy-related 12ENSDARG0000003296344
her15.2 / hairy and enhancer of split-related 15, tandem duplicate 2ENSDARG0000005456042
her15.1 / hairy and enhancer of split-related 15, tandem duplicate 1ENSDARG0000005456242
her4.4 / hairy-related 4, tandem duplicate 4ENSDARG0000000982235
her4.2 / hairy-related 4, tandem duplicate 2ENSDARG0000005672935
her4.1 / hairy-related 4, tandem duplicate 1ENSDARG0000005673235
her4.3 / hairy-related 4, tandem duplicate 3ENSDARG0000007077035
her4.2 / her4.4 / hairy-related 4, tandem duplicate 2ENSDARG0000009442635


Protein motifs (from Interpro)
Interpro ID Name
 IPR003650  Orange domain
 IPR011598  Myc-type, basic helix-loop-helix (bHLH) domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II IEA
 biological_processGO:0007405 neuroblast proliferation IMP
 biological_processGO:0042063 gliogenesis IMP
 biological_processGO:0045664 regulation of neuron differentiation IGI
 biological_processGO:0045665 negative regulation of neuron differentiation IMP
 biological_processGO:0045892 negative regulation of transcription, DNA-templated IDA
 cellular_componentGO:0000785 chromatin IDA
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain has fewer parts of type neuronal stem cell , abnormal
brain has fewer parts of type astrocyte , abnormal
brain has extra parts of type neuron , abnormal
brain neuron differentiation increased occurrence , abnormal
brain neural precursor cell proliferation decreased occurrence , abnormal
brain malformed , abnormal
Show

 ZFA:0000054 pericardium pericardium edematous , abnormal
Show

 ZFA:0000110 fourth ventricle fourth ventricle increased size , abnormal
fourth ventricle edematous , abnormal
Show

 ZFA:0000161 third ventricle third ventricle increased size , abnormal
Show

 ZFA:0001115 trunk trunk bent , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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