ENSDARG00000039217


Danio rerio

Features
Gene ID: ENSDARG00000039217
  
Biological name :orc1
  
Synonyms : orc1 / origin recognition complex, subunit 1
  
Possible biological names infered from orthology : Q13415 / Q9Z1N2
  
Species: Danio rerio
  
Chr. number: 6
Strand: 1
Band:
Gene start: 33931095
Gene end: 33950917
  
Corresponding Affymetrix probe sets: Dr.366.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000154560
Ensembl peptide - ENSDARP00000126330
Ensembl peptide - ENSDARP00000110729
NCBI entrez gene - 554509     See in Manteia.
RefSeq - NM_199933
RefSeq - XM_005166281
RefSeq Peptide - NP_956227
swissprot - I3ITQ7
swissprot - F1QLF9
ZFIN ID - ZDB-GENE-030131-6960
Ensembl - ENSDARG00000039217
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ORC1ENSGALG00000010623Gallus gallus
 ORC1ENSG00000085840Homo sapiens
 Orc1ENSMUSG00000028587Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
cdc6 / cell division cycle 6 homolog (S. cerevisiae) / O89033* / Q99741* / cell division cycle 6* / Cell division control *ENSDARG0000000994214


Protein motifs (from Interpro)
Interpro ID Name
 IPR001025  Bromo adjacent homology (BAH) domain
 IPR003593  AAA+ ATPase domain
 IPR003959  ATPase, AAA-type, core
 IPR011991  ArsR-like helix-turn-helix domain
 IPR015163  Cdc6, C-terminal
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001878 response to yeast IDA
 biological_processGO:0040014 regulation of multicellular organism growth IMP
 biological_processGO:0043009 chordate embryonic development IMP
 molecular_functionGO:0003682 chromatin binding IEA
 molecular_functionGO:0005524 ATP binding IEA


Pathways (from Reactome)
Pathway description
Activation of ATR in response to replication stress
Assembly of the ORC complex at the origin of replication
CDC6 association with the ORC:origin complex
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000107 eye eye decreased size , abnormal
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 ZFA:0001094 whole organism whole organism dwarf-like , abnormal
whole organism anatomical surface decreased area , abnormal
whole organism decreased length , abnormal
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 ZFA:0001227 mandibular arch skeleton mandibular arch skeleton hypoplastic , abnormal
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 ZFA:0001617 otolith otolith decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000008805 orc3 / origin recognition complex, subunit 3 / Q9JK30* / Q9UBD5*  / complex / reaction
 ENSDARG00000021579 orc5 / origin recognition complex, subunit 5 / O43913* / Q9WUV0*  / complex / reaction
 ENSDARG00000075682 orc6 / origin recognition complex, subunit 6 / Q9Y5N6*  / reaction
 ENSDARG00000101161 orc4 / origin recognition complex, subunit 4 / O43929*  / complex / reaction






 

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