ENSDARG00000040237


Danio rerio

Features
Gene ID: ENSDARG00000040237
  
Biological name :mef2d
  
Synonyms : mef2d / myocyte enhancer factor 2d
  
Possible biological names infered from orthology : Myocyte-specific enhancer factor 2D / Q14814 / Q63943
  
Species: Danio rerio
  
Chr. number: 16
Strand: -1
Band:
Gene start: 29072874
Gene end: 29194517
  
Corresponding Affymetrix probe sets: Dr.1403.1.S1_at (Zebrafish Array)   Dr.25090.1.A1_at (Zebrafish Array)   Dr.7439.1.A1_at (Zebrafish Array)   NM_131317_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000027449
Ensembl peptide - ENSDARP00000123748
Ensembl peptide - ENSDARP00000139550
Ensembl peptide - ENSDARP00000046113
Ensembl peptide - ENSDARP00000115546
NCBI entrez gene - 30580     See in Manteia.
RefSeq - NM_131317
RefSeq Peptide - NP_571392
swissprot - F1Q910
swissprot - F1QE20
swissprot - F8W591
ZFIN ID - ZDB-GENE-990415-164
Ensembl - ENSDARG00000040237
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MEF2DENSGALG00000037787Gallus gallus
 MEF2DENSG00000116604Homo sapiens
 Mef2dENSMUSG00000001419Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
mef2aa / myocyte enhancer factor 2aa / MEF2A* / Q60929* / Q02078* / myocyte enhancer factor 2A* / Mus musculus myocyte enhancer factor 2A (Mef2a), transcript variant 7, mRNA.*ENSDARG0000003175647
mef2cb / myocyte enhancer factor 2cb / MEF2C* / Q8CFN5* / Q06413* / myocyte enhancer factor 2C* / Mus musculus myocyte enhancer factor 2C (Mef2c), transcript variant 14, mRNA.*ENSDARG0000000941845
mef2ca / myocyte enhancer factor 2caENSDARG0000002976445
mef2ab / myocyte enhancer factor 2abENSDARG0000005752732
mef2b / myocyte enhancer factor 2b / Q02080* / BORCS8-MEF2B* / BORCS8-MEF2B readthrough*ENSDARG0000009317027


Protein motifs (from Interpro)
Interpro ID Name
 IPR002100  Transcription factor, MADS-box
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR022102  Holliday junction regulator protein family C-terminal
 IPR033896  MADS MEF2-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030241 skeletal muscle myosin thick filament assembly IGI
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IDA
 biological_processGO:0060914 heart formation IGI
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0000976 transcription regulatory region sequence-specific DNA binding IDA
 molecular_functionGO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0046983 protein dimerization activity IEA


Pathways (from Reactome)
Pathway description
CDO in myogenesis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000114 heart heart aplastic , abnormal
Show

 ZFA:0000115 heart rudiment heart rudiment aplastic , abnormal
heart rudiment cardiac muscle cell disorganized , abnormal
Show

 ZFA:0001117 post-vent region post-vent region curved ventral , abnormal
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 ZFA:0001285 intersegmental vessel intersegmental vessel morphology , abnormal
intersegmental vessel decreased length , abnormal
Show

 ZFA:0009116 slow muscle cell slow muscle cell myofibril composition , abnormal
slow muscle cell immature , abnormal
Show

 ZFA:0009117 fast muscle cell fast muscle cell myofibril composition , abnormal
Show

 ZFA:0009316 cardiac muscle cell cardiac muscle cell undifferentiated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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