ENSDARG00000043593


Danio rerio

Features
Gene ID: ENSDARG00000043593
  
Biological name :rapgef1a
  
Synonyms : rapgef1a / Rap guanine nucleotide exchange factor (GEF) 1a
  
Possible biological names infered from orthology : Q13905 / RAPGEF1 / Rap guanine nucleotide exchange factor 1 / Rap guanine nucleotide exchange factor (GEF) 1
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 11779547
Gene end: 11835607
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000064016
Ensembl peptide - ENSDARP00000115473
Ensembl peptide - ENSDARP00000147685
Ensembl peptide - ENSDARP00000153047
Ensembl peptide - ENSDARP00000153871
Ensembl peptide - ENSDARP00000154089
Ensembl peptide - ENSDARP00000154542
Ensembl peptide - ENSDARP00000156515
swissprot - F1QA44
swissprot - F1QZX0
ZFIN ID - ZDB-GENE-081105-26
Ensembl - ENSDARG00000043593
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RAPGEF1ENSGALG00000003712Gallus gallus
 Q13905ENSG00000107263Homo sapiens
 Rapgef1ENSMUSG00000039844Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
rapgef1b / Rap guanine nucleotide exchange factor (GEF) 1bENSDARG0000001597171
sos2 / son of sevenless homolog 2 (Drosophila) / Q02384* / Q07890* / Son of sevenless homolog 2 * / SOS Ras/Rho guanine nucleotide exchange factor 2*ENSDARG0000006050619
A2CEA7 / rasgrf2b / Ras protein-specific guanine nucleotide-releasing factor 2b / O14827* / RASGRF2* / ras-specific guanine nucleotide-releasing factor 2 * / Ras protein specific guanine nu...ENSDARG0000000281614
RASGRF1 / si:ch211-234p18.3 / P27671* / Q13972* / Ras protein specific guanine nucleotide releasing factor 1*ENSDARG0000007382414
rasgrf2a / Ras protein-specific guanine nucleotide-releasing factor 2a / O14827* / RASGRF2* / Ras protein specific guanine nucleotide releasing factor 2*ENSDARG0000007505414
si:ch211-251j10.3 / RGL4* / RGL2* / Q61193* / Q8IZJ4* / RALGDS* / O15211* / Q03385* / Q12967* / AL162417.1* / ral guanine nucleotide dissociation stimulator* / ral guanine nucleotide dissoc...ENSDARG000000424099
rgl3a / ral guanine nucleotide dissociation stimulator-like 3a / RGL3* / Q3MIN7* / Q3UYI5* / ral guanine nucleotide dissociation stimulator like 3*ENSDARG000000712139
sos1 / son of sevenless homolog 1 (Drosophila) / Q07889* / Q62245* / Son of sevenless homolog 1 * / SOS Ras/Rac guanine nucleotide exchange factor 1*ENSDARG000001005039
rgl1 / ral guanine nucleotide dissociation stimulator-like 1 / Q60695* / Q9NZL6* / Mus musculus ral guanine nucleotide dissociation stimulator,-like 1 (Rgl1), transcript variant 2, mRNA.*ENSDARG000000059898
rgl2 / ral guanine nucleotide dissociation stimulator-like 2ENSDARG000000077278
B0UXH6 / ralgps1 / Ral GEF with PH domain and SH3 binding motif 1 / Q5JS13* / A2AR50* / Ras-specific guanine nucleotide-releasing factor RalGPS1 *ENSDARG000000683708
ralgps2 / Ral GEF with PH domain and SH3 binding motif 2 / Q86X27* / Q9ERD6*ENSDARG000000265197


Protein motifs (from Interpro)
Interpro ID Name
 IPR000651  Ras-like guanine nucleotide exchange factor, N-terminal
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR019804  Ras guanine-nucleotide exchange factor, conserved site
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA


Pathways (from Reactome)
Pathway description
Frs2-mediated activation
Downstream signal transduction
MET activates RAP1 and RAC1
Regulation of signaling by CBL


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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