ENSDARG00000044059


Danio rerio

Features
Gene ID: ENSDARG00000044059
  
Biological name :lft2
  
Synonyms : lefty2 / lft2
  
Possible biological names infered from orthology : left-right determination factor 1 / left-right determination factor 2 / LEFTY1 / O00292 / O75610 / P57785 / Q64280
  
Species: Danio rerio
  
Chr. number: 17
Strand: -1
Band:
Gene start: 8308182
Gene end: 8312923
  
Corresponding Affymetrix probe sets: Dr.7279.1.S1_at (Zebrafish Array)   NM_130961_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000064677
NCBI entrez gene - 30146     See in Manteia.
RefSeq - NM_130961
RefSeq Peptide - NP_571036
swissprot - F1QWZ9
ZFIN ID - ZDB-GENE-990630-11
Ensembl - ENSDARG00000044059
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LEFTY2ENSGALG00000009256Gallus gallus
 LEFTY1ENSG00000243709Homo sapiens
 LEFTY2ENSG00000143768Homo sapiens
 Lefty1ENSMUSG00000038793Mus musculus
 Lefty2ENSMUSG00000066652Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lft1 / lefty1 / LEFTY2* / Q64280* / O75610* / P57785* / O00292* / left-right determination factor 1* / left-right determination factor 2*ENSDARG0000001992069


Protein motifs (from Interpro)
Interpro ID Name
 IPR001111  TGF-beta, propeptide
 IPR001839  Transforming growth factor-beta, C-terminal
 IPR003942  Left- Right determination factor
 IPR015615  Transforming growth factor-beta-related
 IPR017948  Transforming growth factor beta, conserved site
 IPR029034  Cystine-knot cytokine


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0003128 heart field specification IMP
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation IBA
 biological_processGO:0030509 BMP signaling pathway IBA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043408 regulation of MAPK cascade IBA
 biological_processGO:0048468 cell development IBA
 biological_processGO:0060395 SMAD protein signal transduction IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 molecular_functionGO:0005125 cytokine activity IBA
 molecular_functionGO:0005160 transforming growth factor beta receptor binding IEA
 molecular_functionGO:0008083 growth factor activity IEA


Pathways (from Reactome)
Pathway description
Platelet degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000017 endoderm endoderm endodermal cell decreased amount , abnormal
Show

 ZFA:0000023 forerunner cell group forerunner cell group decreased amount , abnormal
Show

 ZFA:0000028 heart primordium heart primordium left side fused with heart primordium right side, abnormal
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 ZFA:0000107 eye eye fused with eye , abnormal
Show

 ZFA:0001114 head head morphology , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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