ENSDARG00000044954


Danio rerio

Features
Gene ID: ENSDARG00000044954
  
Biological name :slit1a
  
Synonyms : slit1a / slit homolog 1a (Drosophila)
  
Possible biological names infered from orthology : O75093 / Q80TR4 / SLIT1 / slit guidance ligand 1 / Slit homolog 1 protein
  
Species: Danio rerio
  
Chr. number: 13
Strand: -1
Band:
Gene start: 555321
Gene end: 638485
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000105194
Ensembl peptide - ENSDARP00000066079
NCBI entrez gene - 556123     See in Manteia.
RefSeq - NM_001034968
RefSeq Peptide - NP_001030140
swissprot - B8A498
ZFIN ID - ZDB-GENE-030722-3
Ensembl - ENSDARG00000044954
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLIT1ENSGALG00000042871Gallus gallus
 SLIT1ENSG00000187122Homo sapiens
 Slit1ENSMUSG00000025020Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
slit1b / slit homolog 1b (Drosophila) / SLIT1* / Q80TR4* / O75093* / slit guidance ligand 1* / Slit homolog 1 protein *ENSDARG0000009944669
slit2 / slit homolog 2 (Drosophila) / O94813* / Q9R1B9* / slit guidance ligand 2*ENSDARG0000000424663
slit3 / slit homolog 3 (Drosophila) / Q9WVB4* / O75094* / slit guidance ligand 3* / Slit homolog 3 protein *ENSDARG0000003426856
crb1 / crumbs family member 1, photoreceptor morphogenesis associated / 1 * / P82279* / Q8VHS2* / crumbs 1, cell polarity complex component*ENSDARG0000010050616
crb2a / crumbs family member 2a / 2 * / CRB2* / Q5IJ48* / Q80YA8* / crumbs 2, cell polarity complex component*ENSDARG0000006010614
crb2b / crumbs family member 2b / CRB2* / Q5IJ48* / crumbs 2, cell polarity complex component*ENSDARG000000600819
dner / delta/notch-like EGF repeat containing / Q8NFT8*ENSDARG000000610319
dlk2 / delta-like 2 homolog (Drosophila) / 2 * / Q6UY11* / Q8K1E3* / delta like non-canonical Notch ligand 2*ENSDARG000000762475
CR456624.1 / DLL3* / O88516* / Q9NYJ7* / Delta-like protein 3 * / delta like canonical Notch ligand 3*ENSDARG000000795194
CABZ01102109.1 / DLK1* / P80370* / delta like non-canonical Notch ligand 1*ENSDARG000001142264


Protein motifs (from Interpro)
Interpro ID Name
 IPR000152  EGF-type aspartate/asparagine hydroxylation site
 IPR000372  Leucine-rich repeat N-terminal domain
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000742  EGF-like domain
 IPR001611  Leucine-rich repeat
 IPR001791  Laminin G domain
 IPR001881  EGF-like calcium-binding domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR006207  Cystine knot, C-terminal
 IPR013032  EGF-like, conserved site
 IPR013320  Concanavalin A-like lectin/glucanase domain superfamily
 IPR018097  EGF-like calcium-binding, conserved site
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007411 axon guidance NAS
 biological_processGO:0021602 cranial nerve morphogenesis IMP
 biological_processGO:0045773 positive regulation of axon extension IMP
 cellular_componentGO:0005576 extracellular region IEA
 molecular_functionGO:0005509 calcium ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000059 postoptic commissure postoptic commissure decreased width , abnormal
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 ZFA:0009310 retinal ganglion cell retinal ganglion cell axon has extra parts of type retinal ganglion cell presynaptic active zone, abnormal
retinal ganglion cell axon increased branchiness , abnormal
retinal ganglion cell axon collateral increased length , abnormal
retinal ganglion cell collateral sprouting in absence of injury increased occurrence , abnormal
retinal ganglion cell neuron remodeling decreased process quality , abnormal
retinal ganglion cell axon collateral physical object quality , abnormal
retinal ganglion cell collateral sprouting in absence of injury occurrence , abnormal
retinal ganglion cell cysteine-type endopeptidase activity decreased occurrence , abnormal
retinal ganglion cell axon physical object quality , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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