ENSDARG00000045548


Danio rerio
regulationlepbsignalingactivitymetabolicprocessproteinreceptorresponseextracellularhormoneleptinfour-helicalcytokine-likecoreenergyreservelipidsignaltransductiontyrosinephosphorylationstatphosphatidylinositol-kinasetorinsulinappetiteleptin-mediatedpathwaystarvation

Features
Gene ID: ENSDARG00000045548
  
Biological name :lepb
  
Synonyms : lepb / leptin b
  
Possible biological names infered from orthology :
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 19031768
Gene end: 19033805
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000113509
NCBI entrez gene - 564348     See in Manteia.
RefSeq - NM_001030186
RefSeq Peptide - NP_001025357
swissprot - Q5TYZ1
ZFIN ID - ZDB-GENE-041210-183
Ensembl - ENSDARG00000045548
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
lepa / leptin aENSDARG0000009108529


Protein motifs (from Interpro)
Interpro ID Name
 IPR000065  Leptin
 IPR009079  Four-helical cytokine-like, core


Gene Ontology (GO)
cellular metabolic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalresponse to external stimulusregulation of biological qualityresponse to stresscellular metabolic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalresponse to external stimulusregulation of biological qualityresponse to stresscellular metabolic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalresponse to external stimulusregulation of biological qualityresponse to stresscellular metabolic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalresponse to external stimulusregulation of biological qualityresponse to stresscellular metabolic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalresponse to external stimulusregulation of biological qualityresponse to stresscellular metabolic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalresponse to external stimulusregulation of biological qualityresponse to stresscellular metabolic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalresponse to external stimulusregulation of biological qualityresponse to stresscellular metabolic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalresponse to external stimulusregulation of biological qualityresponse to stresscellular metabolic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalresponse to external stimulusregulation of biological qualityresponse to stresscellular metabolic processoxidation-reduction processprimary metabolic processorganic substance metabolic processcell communicationcellular response to stimulusnitrogen compound metabolic processregulation of molecular functionresponse to endogenous stimulusresponse to chemicalresponse to external stimulusregulation of biological qualityresponse to stresscellular mcellular metabolic processoxidation-oxidation-reduction processprimary meprimary metabolic processorganic suorganic substance metabolic processcell commucell communicationcellular rcellular response to stimulusnitrogen cnitrogen compound metabolic processregulationregulation of molecular functionresponse tresponse to endogenous stimulusresponse tresponse to chemicalresponse tresponse to external stimulusregulationregulation of biological qualityresponse tresponse to stress
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
extracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regioncellextracellular regionextracellular regioncellcell
TypeGO IDTermEv.Code
 biological_processGO:0006112 energy reserve metabolic process IBA
 biological_processGO:0006629 lipid metabolic process IBA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007260 tyrosine phosphorylation of STAT protein IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IBA
 biological_processGO:0032008 positive regulation of TOR signaling IBA
 biological_processGO:0032868 response to insulin IBA
 biological_processGO:0038108 negative regulation of appetite by leptin-mediated signaling pathway IBA
 biological_processGO:0042594 response to starvation IDA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IBA
 biological_processGO:1990051 activation of protein kinase C activity IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0005179 hormone activity IBA
 molecular_functionGO:0051428 peptide hormone receptor binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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