ENSDARG00000045658


Danio rerio

Features
Gene ID: ENSDARG00000045658
  
Biological name :msrb3
  
Synonyms : methionine sulfoxide reductase B3 / msrb3
  
Possible biological names infered from orthology : Q8IXL7
  
Species: Danio rerio
  
Chr. number: 4
Strand: -1
Band:
Gene start: 12890668
Gene end: 12914307
  
Corresponding Affymetrix probe sets: Dr.3730.1.A1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000067134
Ensembl peptide - ENSDARP00000120380
Ensembl peptide - ENSDARP00000122154
Ensembl peptide - ENSDARP00000123270
Ensembl peptide - ENSDARP00000155341
NCBI entrez gene - 415184     See in Manteia.
RefSeq - NM_001320378
RefSeq Peptide - NP_001307307
swissprot - F6P046
swissprot - Q5TZH6
swissprot - Q5TZH8
ZFIN ID - ZDB-GENE-040625-74
Ensembl - ENSDARG00000045658
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 MSRB3ENSGALG00000026661Gallus gallus
 MSRB3ENSG00000174099Homo sapiens
 Msrb3ENSMUSG00000051236Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
msrb2 / methionine sulfoxide reductase B2 / Q78J03* / Q9Y3D2* / Methionine-R-sulfoxide reductase B2, mitochondrial *ENSDARG0000001845931


Protein motifs (from Interpro)
Interpro ID Name
 IPR002579  Peptide methionine sulphoxide reductase MrsB
 IPR011057  Mss4-like superfamily
 IPR028427  Peptide methionine sulfoxide reductase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006979 response to oxidative stress IEA
 biological_processGO:0030091 protein repair IEA
 biological_processGO:0048839 inner ear development IMP
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005575 cellular_component ND
 molecular_functionGO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor IEA
 molecular_functionGO:0033743 peptide-methionine (R)-S-oxide reductase activity IEA


Pathways (from Reactome)
Pathway description
Protein repair


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000217 inner ear inner ear decreased size , abnormal
inner ear stereocilium decreased length , abnormal
inner ear stereocilium decreased width , abnormal
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 ZFA:0000243 neuromast neuromast kinocilium decreased length , abnormal
neuromast decreased amount , abnormal
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 ZFA:0000431 semicircular canal semicircular canal malformed , abnormal
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 ZFA:0001617 otolith otolith amount , abnormal
otolith decreased size , abnormal
otolith mislocalised , abnormal
otolith fused with otolith , abnormal
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 ZFA:0009367 neuromast hair cell neuromast hair cell apoptotic process increased process quality , abnormal
neuromast hair cell decreased amount , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000031435 zgc:56493 / TXN* / Txn1* / Q6A555* / Q86VQ3* / P10639* / Q69AB2* / TXNDC2* / TXNDC8* / P10599* / thioredoxin* / thioredoxin 1* / thioredoxin domain containing 2* / thioredoxin domain contai...  / reaction
 ENSDARG00000044125 txn / thioredoxin / Txn1* / Q6A555* / Q86VQ3* / TXNDC8* / P10599* / P10639* / Q69AB2* / TXNDC2* / thioredoxin 1* / thioredoxin domain containing 2* / thioredoxin domain containing 8* / thio...  / reaction






 

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