ENSDARG00000046074


Danio rerio

Features
Gene ID: ENSDARG00000046074
  
Biological name :stk11
  
Synonyms : serine/threonine kinase 11 / stk11
  
Possible biological names infered from orthology : Q15831 / Q9WTK7 / Serine/threonine-protein kinase STK11
  
Species: Danio rerio
  
Chr. number: 2
Strand: 1
Band:
Gene start: 59041081
Gene end: 59063573
  
Corresponding Affymetrix probe sets: Dr.1688.1.A1_at (Zebrafish Array)   NM_001017839_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000067735
Ensembl peptide - ENSDARP00000133503
NCBI entrez gene - 550537     See in Manteia.
RefSeq - NM_001017839
RefSeq Peptide - NP_001017839
swissprot - F1R050
swissprot - A0A0R4II62
ZFIN ID - ZDB-GENE-050417-383
Ensembl - ENSDARG00000046074
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 STK11ENSGALG00000040008Gallus gallus
 STK11ENSG00000118046Homo sapiens
 Stk11ENSMUSG00000003068Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
camkk1b / calcium/calmodulin-dependent protein kinase kinase 1, alpha b / CAMKK1* / Q8N5S9* / Q8VBY2* / calcium/calmodulin dependent protein kinase kinase 1*ENSDARG0000001513426
camkk1a / calcium/calmodulin-dependent protein kinase kinase 1, alpha a / CAMKK1* / Q8N5S9* / Q8VBY2* / calcium/calmodulin dependent protein kinase kinase 1*ENSDARG0000003545226
si:ch73-62l21.1 / CAMKK2* / Q8C078* / Q96RR4* / calcium/calmodulin dependent protein kinase kinase 2*ENSDARG0000007864521


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site
 IPR020636  Calcium/calmodulin-dependent/calcium-dependent protein kinase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007399 nervous system development IBA
 biological_processGO:0018105 peptidyl-serine phosphorylation IBA
 biological_processGO:0018107 peptidyl-threonine phosphorylation IBA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0035556 intracellular signal transduction IBA
 biological_processGO:0042593 glucose homeostasis IMP
 biological_processGO:0048565 digestive tract development IMP
 biological_processGO:0060575 intestinal epithelial cell differentiation IMP
 biological_processGO:0071902 positive regulation of protein serine/threonine kinase activity IBA
 biological_processGO:0097009 energy homeostasis IMP
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0030295 protein kinase activator activity IBA


Pathways (from Reactome)
Pathway description
Energy dependent regulation of mTOR by LKB1-AMPK
Regulation of TP53 Activity through Phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000037 anatomical structure anatomical structure increased amount , abnormal
anatomical structure decreased amount , abnormal
anatomical structure absent , abnormal
Show

 ZFA:0000123 liver liver color , abnormal
liver decreased size , abnormal
liver fatty , abnormal
liver increased amount , abnormal
liver decreased amount , abnormal
liver low brightness , abnormal
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 ZFA:0001094 whole organism whole organism viability , abnormal
whole organism decreased weight , abnormal
whole organism increased acidity , abnormal
whole organism decreased amount , abnormal
whole organism dead , abnormal
whole organism decreased life span , abnormal
whole organism life span , ameliorated
whole organism absent , abnormal
Show

 ZFA:0001338 intestine intestine increased diameter , abnormal
intestine goblet cell present , abnormal
intestine decreased diameter , abnormal
intestine increased amount , abnormal
intestine decreased amount , abnormal
intestine flattened , abnormal
Show

 ZFA:0005124 intestinal epithelium intestinal epithelium brush border increased height , abnormal
intestinal epithelium epithelial cell increased amount , abnormal
intestinal epithelium flattened , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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