ENSDARG00000051854


Danio rerio
dnareplicationcdt1cdtcomplexcellorcpre-replicativearsr-likehelix-turn-helixdomaingeminin-bindingdomain-likefactorc-terminalcheckpointmitoticcycleregulationdna-dependentinitiationchromosomeorganizationnucleuscytoplasmproteinbindingassociationcdcoriginassembly

Features
Gene ID: ENSDARG00000051854
  
Biological name :cdt1
  
Synonyms : cdt1 / chromatin licensing and DNA replication factor 1
  
Possible biological names infered from orthology : DNA replication factor Cdt1 / Q8R4E9 / Q9H211
  
Species: Danio rerio
  
Chr. number: 7
Strand: 1
Band:
Gene start: 55518519
Gene end: 55530612
  
Corresponding Affymetrix probe sets: Dr.1019.1.A1_at (Zebrafish Array)   XM_690072_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000124390
Ensembl peptide - ENSDARP00000089247
NCBI entrez gene - 566787     See in Manteia.
RefSeq - XM_690072
swissprot - F8W3F6
swissprot - E7F2R5
ZFIN ID - ZDB-GENE-070111-1
Ensembl - ENSDARG00000051854
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CDT1ENSGALG00000013784Gallus gallus
 CDT1ENSG00000167513Homo sapiens
 Cdt1ENSMUSG00000006585Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR011991  ArsR-like helix-turn-helix domain
 IPR014939  CDT1 Geminin-binding domain-like
 IPR032054  DNA replication factor Cdt1, C-terminal


Gene Ontology (GO)
cell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell cyclenitrogen compound metabolic processbiosynthetic processcellular metabolic processprimary metabolic processorganic substance metabolic processcellular component organizationcell cyclecell cyclenitrogen compound menitrogen compound metabolic processbiosynthetic processbiosynthetic processcellular metabolic pcellular metabolic processprimary metabolic prprimary metabolic processorganic substance meorganic substance metabolic processcellular component ocellular component organization
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellorganellecellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0000076 DNA replication checkpoint IBA
 biological_processGO:0000278 mitotic cell cycle IMP
 biological_processGO:0006260 DNA replication IBA
 biological_processGO:0030174 regulation of DNA-dependent DNA replication initiation IBA
 biological_processGO:0051276 chromosome organization IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005737 cytoplasm IBA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
CDT1 association with the CDC6:ORC:origin complex
Assembly of the pre-replicative complex
Orc1 removal from chromatin
Activation of the pre-replicative complex


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000092 axis axis increased length , abnormal
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 ZFA:0000117 hypoblast hypoblast apoptotic , abnormal
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 ZFA:0001094 whole organism whole organism cell polyploid , abnormal
whole organism cell tetraploid , abnormal
whole organism cell endopolyploid , abnormal
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 ZFA:0009000 cell cell increased size , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000026577 cdk2 / cyclin-dependent kinase 2 / P24941* / P97377*  / reaction
 ENSDARG00000045815 mcm10 / Q5RHY1 / minichromosome maintenance 10 replication initiation factor / Q0VBD2* / Q7L590*  / complex / reaction






 

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