ENSDARG00000059090


Danio rerio
receptorsstr2asomatostatincoupledg-proteinsignalingpathwaymembraneactivitygrhodopsin-likesignalcellularresponsestimulusintegralcomponentprotein-coupledfamilygpcrtmtransductioncyclicnucleotidesecondmessengerregulationcellproliferationglucocorticoidestradiol

Features
Gene ID: ENSDARG00000059090
  
Biological name :sstr2a
  
Synonyms : somatostatin receptor 2a / sstr2a
  
Possible biological names infered from orthology : P30874 / P30875 / somatostatin receptor 2 / Somatostatin receptor type 2 / SSTR2
  
Species: Danio rerio
  
Chr. number: 12
Strand: -1
Band:
Gene start: 1556147
Gene end: 1557286
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000076547
NCBI entrez gene - 100333578     See in Manteia.
swissprot - E7FDL0
ZFIN ID - ZDB-GENE-140130-1
Ensembl - ENSDARG00000059090
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SSTR2ENSGALG00000004418Gallus gallus
 SSTR2ENSG00000180616Homo sapiens
 Sstr2ENSMUSG00000047904Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
sstr2b / somatostatin receptor 2b / SSTR2* / P30874* / somatostatin receptor 2*ENSDARG0000006980661
sstr3 / somatostatin receptor 3 / P30935* / P32745* / Somatostatin receptor type 3 *ENSDARG0000001447746
sstr5 / somatostatin receptor 5 / O08858* / P35346* / Somatostatin receptor type 5 *ENSDARG0000010165545
si:zfos-169g10.2 / SSTR3* / P32745* / P30935* / somatostatin receptor 3* / Somatostatin receptor type 3 *ENSDARG0000010366245
sstr1a / somatostatin receptor 1a / SSTR1* / P30872* / P30873* / somatostatin receptor 1*ENSDARG0000010492242
sstr1b / somatostatin receptor 1b / SSTR4* / P31391* / somatostatin receptor 4*ENSDARG0000006792541
npbwr2a / neuropeptides B/W receptor 2a / NPBWR2* / P48146* / neuropeptides B and W receptor 2*ENSDARG0000007942336
oprk1 / opioid receptor, kappa 1 / P33534* / P41145* / Kappa-type opioid receptor *ENSDARG0000000689435
oprm1 / opioid receptor, mu 1 / P35372* / P42866*ENSDARG0000003943434
oprl1 / opiate receptor-like 1 / P41146* / P35377* / opioid receptor-like 1* / opioid related nociceptin receptor 1*ENSDARG0000007120934
oprd1a / opioid receptor, delta 1a / OPRD1* / P32300* / P41143* / opioid receptor delta 1*ENSDARG0000004166033
oprd1b / opioid receptor, delta 1b / OPRD1* / P32300* / P41143* / opioid receptor delta 1*ENSDARG0000003715932
mchr1b / melanin-concentrating hormone receptor 1b / MCHR1* / Q99705* / Q8JZL2* / melanin concentrating hormone receptor 1*ENSDARG0000002252528
mchr2 / melanin-concentrating hormone receptor 2ENSDARG0000003611724
mchr1a / melanin-concentrating hormone receptor 1a / MCHR1* / Q99705* / Q8JZL2* / melanin concentrating hormone receptor 1*ENSDARG0000010409323
MCHR2 / si:dkey-165n16.5 / Q969V1* / melanin concentrating hormone receptor 2*ENSDARG0000000784222


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000586  Somatostatin receptor family
 IPR002074  Somatostatin receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
cell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcell communicationcellular response to stimulusresponse to endogenous stimulusresponse to chemicalcell communicationcell communicationcellular response to stimuluscellular response to stimulusresponse to endogenous stimulusresponse to endogenous stimulusresponse to chemicalresponse to chemical
signaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activityamide bindingsignaling receptor activitysignaling receptor activityamide bindingamide binding
cellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellmembranecellcellmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
 biological_processGO:0008285 negative regulation of cell proliferation IBA
 biological_processGO:0038170 somatostatin signaling pathway IEA
 biological_processGO:0071385 cellular response to glucocorticoid stimulus IBA
 biological_processGO:0071392 cellular response to estradiol stimulus IBA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043005 neuron projection IBA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004994 somatostatin receptor activity IBA
 molecular_functionGO:0042923 neuropeptide binding IBA


Pathways (from Reactome)
Pathway description
Peptide ligand-binding receptors
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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