ENSDARG00000060620


Danio rerio

Features
Gene ID: ENSDARG00000060620
  
Biological name :lig4
  
Synonyms : lig4 / ligase IV, DNA, ATP-dependent
  
Possible biological names infered from orthology : DNA ligase 4 / P49917 / Q8BTF7
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 29267841
Gene end: 29271473
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000080083
NCBI entrez gene - 569525     See in Manteia.
RefSeq - NM_001103123
RefSeq - XM_005159958
RefSeq Peptide - NP_001096593
swissprot - F1Q9E8
ZFIN ID - ZDB-GENE-070820-10
Ensembl - ENSDARG00000060620
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 LIG4ENSGALG00000016854Gallus gallus
 LIG4ENSG00000174405Homo sapiens
 Lig4ENSMUSG00000049717Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000977  DNA ligase, ATP-dependent
 IPR001357  BRCT domain
 IPR012308  DNA ligase, ATP-dependent, N-terminal
 IPR012309  DNA ligase, ATP-dependent, C-terminal
 IPR012310  DNA ligase, ATP-dependent, central
 IPR012340  Nucleic acid-binding, OB-fold
 IPR016059  DNA ligase, ATP-dependent, conserved site
 IPR021536  DNA ligase IV domain
 IPR029710  DNA ligase 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006260 DNA replication IEA
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006297 nucleotide-excision repair, DNA gap filling IBA
 biological_processGO:0006303 double-strand break repair via nonhomologous end joining IMP
 biological_processGO:0006310 DNA recombination IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0033152 immunoglobulin V(D)J recombination IBA
 biological_processGO:0051103 DNA ligation involved in DNA repair IBA
 biological_processGO:0071897 DNA biosynthetic process IEA
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0005958 DNA-dependent protein kinase-DNA ligase 4 complex IBA
 cellular_componentGO:0032807 DNA ligase IV complex IBA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003909 DNA ligase activity IEA
 molecular_functionGO:0003910 DNA ligase (ATP) activity IBA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016874 ligase activity IEA


Pathways (from Reactome)
Pathway description
Nonhomologous End-Joining (NHEJ)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000075083 prkdc / protein kinase, DNA-activated, catalytic polypeptide / P78527* / P97313* / DNA-dependent protein kinase catalytic subunit *  / reaction
 ENSDARG00000010732 xrcc4 / X-ray repair complementing defective repair in Chinese hamster cells 4 / Q13426* / X-ray repair cross complementing 4*  / complex
 ENSDARG00000045704 Q5RGE5 / dclre1c / DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae) / Q96SD1* / Q8K4J0* / Protein artemis * / DNA cross-link repair 1C*  / reaction
 ENSDARG00000071551 xrcc6 / X-ray repair complementing defective repair in Chinese hamster cells 6 / P12956* / X-ray repair cross complementing 6*  / reaction
 ENSDARG00000099298 xrcc5 / X-ray repair complementing defective repair in Chinese hamster cells 5 / P13010* / X-ray repair cross complementing 5*  / reaction






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr