ENSDARG00000060734


Danio rerio

Features
Gene ID: ENSDARG00000060734
  
Biological name :appl1
  
Synonyms : adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 / appl1 / hesx1
  
Possible biological names infered from orthology : adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 / DCC-interacting protein 13-alpha / Q8K3H0 / Q9UKG1
  
Species: Danio rerio
  
Chr. number: 11
Strand: 1
Band:
Gene start: 42600731
Gene end: 42635440
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000150187
Ensembl peptide - ENSDARP00000080303
Ensembl peptide - ENSDARP00000155589
Ensembl peptide - ENSDARP00000071182
NCBI entrez gene - 571540     See in Manteia.
RefSeq - NM_001128074
RefSeq Peptide - NP_001121546
swissprot - F1QA18
swissprot - F1QBG1
ZFIN ID - ZDB-GENE-081016-1
ZFIN ID - ZDB-GENE-990415-130
Ensembl - ENSDARG00000060734
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 APPL1ENSGALG00000005527Gallus gallus
 APPL1ENSG00000157500Homo sapiens
 Appl1ENSMUSG00000040760Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
appl2 / adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 / Q8NEU8* / adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2*ENSDARG0000007813946


Protein motifs (from Interpro)
Interpro ID Name
 IPR001356  Homeobox domain
 IPR001849  Pleckstrin homology domain
 IPR006020  PTB/PI domain
 IPR009057  Homeobox-like domain superfamily
 IPR011993  PH-like domain superfamily
 IPR017970  Homeobox, conserved site
 IPR027267  AH/BAR domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0030900 forebrain development IGI
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005768 endosome IGI
 cellular_componentGO:0005769 early endosome IDA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA


Pathways (from Reactome)
Pathway description
via Dependence Receptors in the absence of ligand


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000079 telencephalon telencephalon apoptotic , abnormal
Show

 ZFA:0000101 diencephalon diencephalon decreased size , abnormal
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 ZFA:0000106 extension extension decreased size , abnormal
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 ZFA:0000109 forebrain forebrain apoptotic , abnormal
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 ZFA:0000151 pronephros pronephros apoptotic , abnormal
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 ZFA:0000402 olfactory bulb olfactory bulb apoptotic , abnormal
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 ZFA:0001094 whole organism whole organism lacks all parts of type telencephalon , abnormal
whole organism lacks all parts of type eye , abnormal
whole organism apoptotic , abnormal
whole organism bent , abnormal
whole organism edematous , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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