ENSDARG00000063095


Danio rerio
peptidasectsfactivitycysteineendopeptidasecysteine-typedomainactivesitecinhibitorproteolysiscystatinpapainc-terminalcathepsinpropeptidehistidineregulationinvolvedcellularproteincatabolicprocessextracellularspacelysosomemhcclassiiantigen

Features
Gene ID: ENSDARG00000063095
  
Biological name :ctsf
  
Synonyms : cathepsin F / ctsf
  
Possible biological names infered from orthology : Q9R013 / Q9UBX1
  
Species: Danio rerio
  
Chr. number: 14
Strand: 1
Band:
Gene start: 7140997
Gene end: 7164646
  
Corresponding Affymetrix probe sets: Dr.8170.1.A1_at (Zebrafish Array)   NM_001077568_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000112297
Ensembl peptide - ENSDARP00000132041
NCBI entrez gene - 565588     See in Manteia.
RefSeq - NM_001077568
RefSeq - XM_005157153
RefSeq Peptide - NP_001071036
swissprot - F1RE14
ZFIN ID - ZDB-GENE-030131-9831
Ensembl - ENSDARG00000063095
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CTSFENSG00000174080Homo sapiens
 CtsfENSMUSG00000083282Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ctsh / cathepsin H / P09668* / P49935*ENSDARG0000004110824
ctsl.1 / cathepsin L.1ENSDARG0000000390223
ctsla / cathepsin LaENSDARG0000000783623
ctss2.2 / cathepsin S, ortholog 2, tandem duplicate 2 / CTSS* / O70370* / P25774* / cathepsin S*ENSDARG0000001377122
ctslb / cathepsin Lb / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / CTSV* / Cts3* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q9JI81...ENSDARG0000003917322
ctsk / cathepsin K / P43235* / P55097*ENSDARG0000004025122
cts12 / cathepsin 12ENSDARG0000004275322
ctslb / cathepsin Lb / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / CTSV* / Cts3* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q9JI81...ENSDARG0000007430622
zgc:174154 / Cts8* / Cts3* / Cts6* / Cts7* / Ctsj* / CTSL* / Ctsm* / Ctsq* / Ctsr* / CTSV* / Q9JIA9* / O60911* / Ctsll3* / Q9R014* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JI81* / BC0516...ENSDARG0000007552722
zgc:110239ENSDARG0000007766422
zgc:174153 / Cts8* / Cts3* / Cts6* / Cts7* / Ctsj* / CTSL* / Ctsm* / Ctsq* / Ctsr* / CTSV* / Q9JIA9* / O60911* / Ctsll3* / Q9R014* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JI81* / BC0516...ENSDARG0000007937622
si:dkey-26g8.5 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / BC...ENSDARG0000008975022
si:dkey-239j18.3 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / ...ENSDARG0000008980622
zgc:174855 / Cts8* / Cts3* / Cts6* / Cts7* / Ctsj* / CTSL* / Ctsm* / Ctsq* / Ctsr* / CTSV* / Q9JIA9* / O60911* / Ctsll3* / Q9R014* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JI81* / BC0516...ENSDARG0000009455922
MGC174155 / Cathepsin L1-like / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / Cts3* / CTSV* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0*...ENSDARG0000009507222
si:dkey-239j18.2 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / ...ENSDARG0000009525422
si:dkey-269i1.4 / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts7* / Cts3* / Cts6* / CTSV* / Q9JI81* / Q9R014* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q91ZF2* / Q9JIA9* / B...ENSDARG0000009574422
si:dkey-269i1.4 / CTSL* / CTSV* / O60911* / P07711* / cathepsin V* / cathepsin L*ENSDARG0000010083322
ctsll / cathepsin L, like / Ctsr* / Ctsq* / Ctsm* / CTSL* / Ctsj* / Cts8* / Cts6* / Cts7* / CTSV* / Cts3* / Q91ZF2* / Q9R014* / Q9JIA9* / Ctsll3* / O60911* / P06797* / P07711* / Q80UB0* / Q...ENSDARG0000001170121
ctss2.1 / cathepsin S, ortholog2, tandem duplicate 1 / CTSS* / O70370* / P25774* / cathepsin S*ENSDARG0000007465621


Protein motifs (from Interpro)
Interpro ID Name
 IPR000010  Cystatin domain
 IPR000169  Cysteine peptidase, cysteine active site
 IPR000668  Peptidase C1A, papain C-terminal
 IPR013128  Peptidase C1A
 IPR013201  Cathepsin propeptide inhibitor domain (I29)
 IPR025660  Cysteine peptidase, histidine active site


Gene Ontology (GO)
nitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular metabolic processregulation of molecular functioncatabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular metabolic processregulation of molecular functioncatabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular metabolic processregulation of molecular functioncatabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular metabolic processregulation of molecular functioncatabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular metabolic processregulation of molecular functioncatabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular metabolic processregulation of molecular functioncatabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular metabolic processregulation of molecular functioncatabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular metabolic processregulation of molecular functioncatabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular metabolic processregulation of molecular functioncatabolic processnitrogen compound metabolic processprimary metabolic processorganic substance metabolic processcellular metabolic processregulation of molecular functioncatabolic processnitrogen compound metabnitrogen compound metabolic processprimary metabolic proceprimary metabolic processorganic substance metaborganic substance metabolic processcellular metabolic proccellular metabolic processregulation of molecularregulation of molecular functioncatabolic processcatabolic process
catalytic activity, acting on a proteinhydrolase activityenzyme regulator activitycatalytic activity, acting on a proteinhydrolase activityenzyme regulator activitycatalytic activity, acting on a proteinhydrolase activityenzyme regulator activitycatalytic activity, acting on a proteinhydrolase activityenzyme regulator activitycatalytic activity, acting on a proteinhydrolase activityenzyme regulator activitycatalytic activity, acting on a proteinhydrolase activityenzyme regulator activitycatalytic activity, acting on a proteinhydrolase activityenzyme regulator activitycatalytic activity, acting on a proteinhydrolase activityenzyme regulator activitycatalytic activity, acting on a proteinhydrolase activityenzyme regulator activitycatalytic activity, acting on a proteinhydrolase activityenzyme regulator activitycatalytic activity, acting on a proteincatalytic activity, acting on a proteinhydrolase activityhydrolase activityenzyme regulator activityenzyme regulator activity
extracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regioncellorganelleextracellular regionextracellular regioncellcellorganelleorganelle
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0010951 negative regulation of endopeptidase activity IEA
 biological_processGO:0051603 proteolysis involved in cellular protein catabolic process IBA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005764 lysosome IBA
 molecular_functionGO:0004197 cysteine-type endopeptidase activity IBA
 molecular_functionGO:0004869 cysteine-type endopeptidase inhibitor activity IEA
 molecular_functionGO:0008234 cysteine-type peptidase activity IEA


Pathways (from Reactome)
Pathway description
MHC class II antigen presentation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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