ENSDARG00000069765


Danio rerio

Features
Gene ID: ENSDARG00000069765
  
Biological name :syngap1b
  
Synonyms : synaptic Ras GTPase activating protein 1b / syngap1b
  
Possible biological names infered from orthology : F6SEU4 / Q96PV0 / Ras/Rap GTPase-activating protein SynGAP / synaptic Ras GTPase activating protein 1 / SYNGAP1
  
Species: Danio rerio
  
Chr. number: 16
Strand: 1
Band:
Gene start: 45456066
Gene end: 45691220
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000087797
Ensembl peptide - ENSDARP00000122011
NCBI entrez gene - 100151149     See in Manteia.
RefSeq - NM_001326467
RefSeq Peptide - NP_001313396
swissprot - E9QHX3
swissprot - E7F1U4
ZFIN ID - ZDB-GENE-100921-2
Ensembl - ENSDARG00000069765
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Q96PV0ENSG00000197283Homo sapiens
 F6SEU4ENSMUSG00000067629Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
syngap1a / synaptic Ras GTPase activating protein 1a / Q96PV0* / F6SEU4* / SYNGAP1* / synaptic Ras GTPase activating protein 1* / Ras/Rap GTPase-activating protein SynGAP *ENSDARG0000006371366
dab2ipa / DAB2 interacting protein a / Q3UHC7* / DAB2IP* / Q5VWQ8* / DAB2 interacting protein* / Disabled homolog 2-interacting protein *ENSDARG0000006948438
dab2ipb / DAB2 interacting protein bENSDARG0000007511038
rasal2 / RAS protein activator like 2 / Q9UJF2*ENSDARG0000003625737
rasal3 / RAS protein activator like 3 / Q86YV0* / Q8C2K5*ENSDARG0000008993323
rasa1a / RAS p21 protein activator (GTPase activating protein) 1a / RASA1* / P20936* / RAS p21 protein activator 1*ENSDARG0000003553512
rasa1b / RAS p21 protein activator (GTPase activating protein) 1b / RASA1* / P20936* / RAS p21 protein activator 1*ENSDARG0000007366512
rasa4 / RAS p21 protein activator 4 / RASA4B* / C9J798* / O43374* / Q6PFQ7* / RAS p21 protein activator 4B*ENSDARG0000002937210
rasa3 / RAS p21 protein activator 3 / Q14644* / Q60790* / Ras GTPase-activating protein 3 *ENSDARG0000006337110
CABZ01005876.1 / RASA2* / Q15283* / RAS p21 protein activator 2*ENSDARG000000787759
rasal1b / RAS protein activator like 1b (GAP1 like) / Q9Z268* / RASAL1* / O95294* / RAS protein activator like 1* / Mus musculus RAS protein activator like 1 (GAP1 like) (Rasal1), transcrip...ENSDARG000000415153


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR001849  Pleckstrin homology domain
 IPR001936  Ras GTPase-activating domain
 IPR008936  Rho GTPase activation protein
 IPR011993  PH-like domain superfamily
 IPR021887  Domain of unknown function DUF3498
 IPR023152  Ras GTPase-activating protein, conserved site
 IPR023315  SynGAP C2 domain, N-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0036269 swimming behavior IMP
 biological_processGO:0043087 regulation of GTPase activity IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0046580 negative regulation of Ras protein signal transduction IBA
 biological_processGO:0048854 brain morphogenesis IMP
 cellular_componentGO:0005737 cytoplasm IBA
 cellular_componentGO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane IBA
 molecular_functionGO:0005096 GTPase activator activity IBA


Pathways (from Reactome)
Pathway description
Regulation of RAS by GAPs


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain decreased size , abnormal
Show

 ZFA:0000029 hindbrain hindbrain GABAergic neuron decreased amount , abnormal
hindbrain glutamatergic neuron decreased amount , abnormal
hindbrain apoptotic , abnormal
Show

 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary morphology , abnormal
Show

 ZFA:0000075 spinal cord spinal cord apoptotic , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
Show

 ZFA:0000128 midbrain midbrain GABAergic neuron decreased amount , abnormal
midbrain apoptotic , abnormal
Show

 ZFA:0001094 whole organism whole organism dead , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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