ENSDARG00000076994


Danio rerio

Features
Gene ID: ENSDARG00000076994
  
Biological name :adgra2
  
Synonyms : adgra2 / adhesion G protein-coupled receptor A2 / E7FBY6
  
Possible biological names infered from orthology : Q91ZV8 / Q96PE1
  
Species: Danio rerio
  
Chr. number: 8
Strand: -1
Band:
Gene start: 38026683
Gene end: 38159805
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000103078
Ensembl peptide - ENSDARP00000115239
Ensembl peptide - ENSDARP00000155950
swissprot - E7FBY6
swissprot - F1Q989
ZFIN ID - ZDB-GENE-081104-363
Ensembl - ENSDARG00000076994
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ADGRA2ENSGALG00000003118Gallus gallus
 ADGRA2ENSG00000020181Homo sapiens
 Adgra2ENSMUSG00000031486Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
adgra3 / adhesion G protein-coupled receptor A3 / Q8IWK6*ENSDARG0000007367317
adgra1a / adhesion G protein-coupled receptor A1aENSDARG0000005417713
lrig1 / leucine-rich repeats and immunoglobulin-like domains 1 / P70193* / Q96JA1* / Leucine-rich repeats and immunoglobulin-like domains protein 1 *ENSDARG0000007562511
lrig2 / leucine-rich repeats and immunoglobulin-like domains 2 / O94898* / Q52KR2*ENSDARG0000007856111
lgi1a / leucine-rich, glioma inactivated 1a / LGI4* / Q8N135* / leucine rich repeat LGI family member 4*ENSDARG000000204936
lgi3 / leucine-rich repeat LGI family, member 3 / Q8K406* / Q8N145*ENSDARG000000413586
lgi1b / leucine-rich, glioma inactivated 1b / LGI4* / Q8K1S1* / Q8N135* / leucine rich repeat LGI family member 4*ENSDARG000000584216
lgi2b / leucine-rich repeat LGI family, member 2b / LGI2* / Q8K4Z0* / Q8N0V4* / leucine rich repeat LGI family member 2*ENSDARG000000697016
vasna / vasorin a / VASN* / Q6EMK4* / vasorin*ENSDARG000000992666
vasnb / vasorin b / VASN* / Q9CZT5* / Q6EMK4* / vasorin*ENSDARG000001025656
lgi2a / leucine-rich repeat LGI family, member 2a / LGI2* / Q8N0V4* / leucine rich repeat LGI family member 2*ENSDARG000001110695


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000832  GPCR, family 2, secretin-like
 IPR001611  Leucine-rich repeat
 IPR001879  GPCR, family 2, extracellular hormone receptor domain
 IPR003591  Leucine-rich repeat, typical subtype
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR013783  Immunoglobulin-like fold
 IPR017981  GPCR, family 2-like
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis IEA
 biological_processGO:0001944 vasculature development IMP
 biological_processGO:0002040 sprouting angiogenesis IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007399 nervous system development IEA
 biological_processGO:0016055 Wnt signaling pathway IMP
 biological_processGO:0022009 central nervous system vasculogenesis IMP
 biological_processGO:1990791 dorsal root ganglion development IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain endothelial cell development decreased occurrence , abnormal
brain blood vessel morphology , abnormal
brain endothelial cell decreased amount , abnormal
brain endothelial cell absent , abnormal
Show

 ZFA:0000029 hindbrain hindbrain central artery absent , abnormal
hindbrain central artery decreased amount , abnormal
Show

 ZFA:0000075 spinal cord spinal cord anterior region decreased distribution , abnormal
Show

 ZFA:0000099 brain vasculature brain vasculature absent , abnormal
brain vasculature decreased amount , abnormal
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 ZFA:0000200 dorsal root ganglion dorsal root ganglion Wnt signaling pathway decreased process quality , abnormal
dorsal root ganglion decreased amount , abnormal
dorsal root ganglion absent , abnormal
dorsal root ganglion neuron decreased amount , abnormal
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 ZFA:0001052 primordial hindbrain channel primordial hindbrain channel Wnt signaling pathway decreased process quality , abnormal
primordial hindbrain channel angiogenic sprout absent , abnormal
primordial hindbrain channel sprouting angiogenesis decreased process quality , abnormal
primordial hindbrain channel endothelial tip cell fate specification decreased process quality , abnormal
Show

 ZFA:0001094 whole organism whole organism decreased life span , abnormal
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 ZFA:0001115 trunk trunk neuron decreased distribution , abnormal
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 ZFA:0001463 melanophore stripe melanophore stripe broken , abnormal
melanophore stripe irregular spatial pattern , abnormal
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 ZFA:0005002 basilar artery basilar artery Wnt signaling pathway decreased process quality , abnormal
Show

 ZFA:0005020 central artery central artery absent , abnormal
Show

 ZFA:0007042 spinal cord neural tube spinal cord neural tube anterior region decreased distribution , abnormal
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 ZFA:0009065 endothelial cell endothelial cell filamentous actin decreased accumulation primordial hindbrain channel dorsal region, abnormal
Show

 ZFA:0009091 melanocyte melanocyte decreased amount , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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