ENSDARG00000079922


Danio rerio
intestineklf4cellzincfingerch-typeregulationproliferationnucleicacidbindingoticvesicleswimbladdereyelivertectalventricleposteriorintestinalbulbwholeorganismmidgoblet

Features
Gene ID: ENSDARG00000079922
  
Biological name :klf4
  
Synonyms : klf4 / Kruppel-like factor 4
  
Possible biological names infered from orthology : Krueppel-like factor 4 / O43474 / Q60793
  
Species: Danio rerio
  
Chr. number: 21
Strand: -1
Band:
Gene start: 419801
Gene end: 435466
  
Corresponding Affymetrix probe sets: Dr.9997.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000097662
swissprot - F1QTN3
ZFIN ID - ZDB-GENE-111014-1
Ensembl - ENSDARG00000079922
  
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 KLF4ENSGALG00000026928Gallus gallus
 KLF4ENSG00000136826Homo sapiens
 Klf4ENSMUSG00000003032Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
klf2b / Kruppel-like factor 2b / KLF1* / KLF2* / Q9Y5W3* / Q13351* / Kruppel like factor 1* / Kruppel like factor 2*ENSDARG0000004043229
klf2a / Kruppel-like factor 2a / KLF1* / KLF2* / Q9Y5W3* / Q13351* / Q60843* / Kruppel like factor 2* / Kruppel like factor 1* / Krueppel-like factor 2 *ENSDARG0000004266729
klf17 / Kruppel-like factor 17ENSDARG0000003879223
klf1 / Kruppel-like factor 1 (erythroid)ENSDARG0000001740017
klf15 / Kruppel-like factor 15 / Q9EPW2* / Q9UIH9* / Krueppel-like factor 15 *ENSDARG0000009112716
klf12b / Kruppel-like factor 12b / KLF12* / Q9Y4X4* / O35738* / Kruppel like factor 12* / Krueppel-like factor 12 *ENSDARG0000003219715
klf5a / pibf1 / Kruppel-like factor 5a / KLF5* / Q9Z0Z7* / Q13887* / Kruppel like factor 5* / Krueppel-like factor 5 *ENSDARG0000001550614
klf5l / Kruppel-like factor 5 likeENSDARG0000001875714
klf12a / Kruppel-like factor 12aENSDARG0000001531213
klf3 / Kruppel-like factor 3 (basic) / P57682* / Q60980* / Kruppel like factor 3* / Krueppel-like factor 3 *ENSDARG0000001549512
klf6a / Kruppel-like factor 6a / KLF6* / Q99612* / Kruppel like factor 6*ENSDARG0000002907212
klf6b / Kruppel-like factor 6bENSDARG0000003856111
klf8 / Kruppel-like factor 8 / O95600* / Q8BLM0* / Krueppel-like factor 8 *ENSDARG0000006066111
si:ch211-117k10.3ENSDARG0000009091411
klf7b / Kruppel-like factor 7b / KLF7* / Q99JB0* / O75840* / Kruppel like factor 7* / Krueppel-like factor 7 *ENSDARG0000004382110
klf5b / Kruppel-like factor 5b / KLF5* / Q9Z0Z7* / Q13887* / Kruppel like factor 5* / Krueppel-like factor 5 *ENSDARG0000006210610
klf7a / Kruppel-like factor 7a / KLF7* / Q99JB0* / O75840* / Kruppel like factor 7* / Krueppel-like factor 7 *ENSDARG000000738579


Protein motifs (from Interpro)
Interpro ID Name
 IPR013087  Zinc finger C2H2-type


Gene Ontology (GO)
organic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound binding
TypeGO IDTermEv.Code
 biological_processGO:0008285 negative regulation of cell proliferation IMP
 molecular_functionGO:0003676 nucleic acid binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000051 otic vesicle otic vesicle decreased size , abnormal
Show

 ZFA:0000076 swim bladder swim bladder non-functional , abnormal
Show

 ZFA:0000107 eye eye decreased size , abnormal
Show

 ZFA:0000123 liver liver hypoplastic , abnormal
Show

 ZFA:0000159 tectal ventricle tectal ventricle increased size , abnormal
Show

 ZFA:0000706 posterior intestine posterior intestine goblet cell decreased amount , abnormal
Show

 ZFA:0001076 intestinal bulb intestinal bulb goblet cell decreased amount , abnormal
Show

 ZFA:0001094 whole organism whole organism dorsal-ventral axis decreased length , abnormal
Show

 ZFA:0001323 mid intestine mid intestine goblet cell decreased amount , abnormal
Show

 ZFA:0001338 intestine intestine distended , abnormal
intestine hypoplastic , abnormal
Show

 ZFA:0009094 goblet cell goblet cell decreased amount , abnormal
goblet cell poorly differentiated , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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