ENSDARG00000087921


Danio rerio

Features
Gene ID: ENSDARG00000087921
  
Biological name :plce1
  
Synonyms : phospholipase C, epsilon 1 / plce1
  
Possible biological names infered from orthology : 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 / Q8K4S1 / Q9P212
  
Species: Danio rerio
  
Chr. number: 12
Strand: 1
Band:
Gene start: 5251647
Gene end: 5398578
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000112202
Ensembl peptide - ENSDARP00000126711
NCBI entrez gene - 568288     See in Manteia.
RefSeq - NM_001161653
RefSeq Peptide - NP_001155125
swissprot - F1RET1
swissprot - R4GE01
ZFIN ID - ZDB-GENE-061212-4
Ensembl - ENSDARG00000087921
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ENSGALG00000040799Gallus gallus
 ENSGALG00000039528Gallus gallus
 PLCE1ENSG00000138193Homo sapiens
 Plce1ENSMUSG00000024998Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
plcg2 / phospholipase C, gamma 2 / P16885* / Q8CIH5* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 *ENSDARG0000006876312
plcg1 / phospholipase C, gamma 1 / P19174* / Q62077* / 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 *ENSDARG0000003844211
si:ch211-260p9.3ENSDARG000000928626


Protein motifs (from Interpro)
Interpro ID Name
 IPR000008  C2 domain
 IPR000159  Ras-associating (RA) domain
 IPR000909  Phosphatidylinositol-specific phospholipase C, X domain
 IPR001192  Phosphoinositide phospholipase C family
 IPR001711  Phospholipase C, phosphatidylinositol-specific, Y domain
 IPR001895  Ras guanine-nucleotide exchange factors catalytic domain
 IPR011992  EF-hand domain pair
 IPR015359  Phosphoinositide-specific phospholipase C, EF-hand-like domain
 IPR017946  PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily
 IPR023578  Ras guanine nucleotide exchange factor domain superfamily
 IPR028398  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007264 small GTPase mediated signal transduction IEA
 biological_processGO:0016042 lipid catabolic process IEA
 biological_processGO:0032835 glomerulus development ISS
 biological_processGO:0032836 glomerular basement membrane development IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0005622 intracellular IEA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0008081 phosphoric diester hydrolase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA


Pathways (from Reactome)
Pathway description
Synthesis of IP3 and IP4 in the cytosol


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000084 yolk yolk edematous , abnormal
Show

 ZFA:0001673 pronephric podocyte pronephric podocyte structure , abnormal
pronephric podocyte disorganized , abnormal
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 ZFA:0005313 pronephric glomerular basement membrane pronephric glomerular basement membrane disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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