ENSDARG00000098952


Danio rerio

Features
Gene ID: ENSDARG00000098952
  
Biological name :gata4
  
Synonyms : gata4 / GATA binding protein 4
  
Possible biological names infered from orthology : P43694 / Q08369 / Transcription factor GATA-4
  
Species: Danio rerio
  
Chr. number: 20
Strand: -1
Band:
Gene start: 52952116
Gene end: 52967878
  
Corresponding Affymetrix probe sets: Dr.8216.1.S1_at (Zebrafish Array)   NM_131236_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000135304
NCBI entrez gene - 30483     See in Manteia.
RefSeq - NM_131236
RefSeq Peptide - NP_571311
swissprot - A0A0R4ILP3
ZFIN ID - ZDB-GENE-980526-476
Ensembl - ENSDARG00000098952
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 GATA4ENSGALG00000016662Gallus gallus
 GATA4ENSG00000136574Homo sapiens
 Gata4ENSMUSG00000021944Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
gata6 / GATA binding protein 6 / Q61169* / Q92908* / Transcription factor GATA-6 *ENSDARG0000010358952
gata5 / GATA binding protein 5 / P97489* / Q9BWX5* / Transcription factor GATA-5 *ENSDARG0000001782148
gata2b / GATA binding protein 2bENSDARG0000000909436
gata3 / Q91428 / GATA binding protein 3 / P23771* / P23772* / Mus musculus GATA binding protein 3 (Gata3), transcript variant 3, mRNA.*ENSDARG0000001652636
gata2a / GATA binding protein 2a / GATA2* / O09100* / P23769* / GATA binding protein 2* / Mus musculus GATA binding protein 2 (Gata2), transcript variant 2, mRNA.*ENSDARG0000005932736
gata1a / GATA binding protein 1a / GATA1* / P17679* / P15976* / GATA binding protein 1* / Erythroid transcription factor *ENSDARG0000001347732
gata1b / GATA binding protein 1b / GATA1* / P17679* / P15976* / GATA binding protein 1* / Erythroid transcription factor *ENSDARG0000005913030
trps1 / trichorhinophalangeal syndrome I / Q9UHF7* / transcriptional repressor GATA binding 1*ENSDARG0000010408225


Protein motifs (from Interpro)
Interpro ID Name
 IPR000679  Zinc finger, GATA-type
 IPR008013  GATA-type transcription activator, N-terminal
 IPR013088  Zinc finger, NHR/GATA-type
 IPR016375  Transcription factor GATA-4/5/6


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001889 liver development IMP
 biological_processGO:0001947 heart looping IGI
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0007507 heart development IGI
 biological_processGO:0030099 myeloid cell differentiation IGI
 biological_processGO:0035050 embryonic heart tube development IMP
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IGI
 biological_processGO:0048797 swim bladder formation IGI
 biological_processGO:0055010 ventricular cardiac muscle tissue morphogenesis IMP
 biological_processGO:0060975 cardioblast migration to the midline involved in heart field formation IGI
 biological_processGO:0061026 cardiac muscle tissue regeneration IMP
 cellular_componentGO:0005634 nucleus IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity IEA
 molecular_functionGO:0008270 zinc ion binding IEA
 molecular_functionGO:0043565 sequence-specific DNA binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Factors involved in megakaryocyte development and platelet production


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000009 cardiac ventricle cardiac ventricle decreased distribution , abnormal
Show

 ZFA:0000028 heart primordium heart primordium left side unfused from heart primordium right side, abnormal
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 ZFA:0000076 swim bladder swim bladder uninflated , abnormal
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 ZFA:0000106 extension extension degenerate , abnormal
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 ZFA:0000114 heart heart physical object quality , abnormal
heart bifurcated , abnormal
heart malformed , abnormal
heart absent , abnormal
Show

 ZFA:0000123 liver liver hypoplastic , abnormal
Show

 ZFA:0000243 neuromast neuromast decreased amount , abnormal
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 ZFA:0000360 heart tube heart tube malformed , abnormal
heart tube shape , abnormal
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 ZFA:0000944 posterior lateral line posterior lateral line lacks parts or has fewer parts of type neuromast , abnormal
posterior lateral line neuron projection mislocalised , abnormal
posterior lateral line neuron decreased branchiness , abnormal
Show

 ZFA:0001058 caudal fin caudal fin blood circulation decreased process quality , abnormal
Show

 ZFA:0001094 whole organism whole organism absent , abnormal
Show

 ZFA:0001115 trunk trunk lacks parts or has fewer parts of type neuromast , abnormal
Show

 ZFA:0001286 caudal vein plexus caudal vein plexus malformed , abnormal
Show

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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