ENSDARG00000102632


Danio rerio

Features
Gene ID: ENSDARG00000102632
  
Biological name :ubc
  
Synonyms : ubc / ubiquitin C
  
Possible biological names infered from orthology : P0CG48 / P0CG50
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 44692272
Gene end: 44694732
  
Corresponding Affymetrix probe sets: Dr.25822.1.S1_at (Zebrafish Array)   NM_001077804_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000139647
NCBI entrez gene - 777766     See in Manteia.
RefSeq - NM_001077804
RefSeq Peptide - NP_001071272
swissprot - F1QHN6
ZFIN ID - ZDB-GENE-061110-88
Ensembl - ENSDARG00000102632
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 UBCENSG00000150991Homo sapiens
 UbcENSMUSG00000008348Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ubb / ubiquitin BENSDARG0000009331398
si:ch211-202a12.4 / UBC* / P0CG48* / P0CG50* / ubiquitin C*ENSDARG0000000236985
isg15 / ISG15 ubiquitin-like modifier / P05161* / Q64339* / Ubiquitin-like protein ISG15 *ENSDARG000000863747


Protein motifs (from Interpro)
Interpro ID Name
 IPR000626  Ubiquitin domain
 IPR019954  Ubiquitin conserved site
 IPR019956  Ubiquitin
 IPR029071  Ubiquitin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 molecular_functionGO:0003674 molecular_function ND


Pathways (from Reactome)
Pathway description
ABC-family proteins mediated transport
Regulation of TP53 Activity through Phosphorylation
Regulation of necroptotic cell death
FCERI mediated NF-kB activation
The role of GTSE1 in G2/M progression after G2 checkpoint
PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1
Gap-filling DNA repair synthesis and ligation in GG-NER
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
Regulation of TP53 Activity through Methylation
Negative regulation of MAPK pathway
Negative regulation of FGFR1 signaling
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
TRAF6-mediated induction of TAK1 complex within TLR4 complex
RUNX1 regulates transcription of genes involved in differentiation of HSCs
IRAK2 mediated activation of TAK1 complex
NOTCH3 Activation and Transmission of Signal to the Nucleus
Translesion synthesis by REV1
Downregulation of SMAD2/3:SMAD4 transcriptional activity
Translesion synthesis by POLI
Antigen processing: Ubiquitination & Proteasome degradation
Ovarian tumor domain proteases
Negative regulation of FGFR3 signaling
Cargo recognition for clathrin-mediated endocytosis
Regulation of PTEN localization
Metalloprotease DUBs
Translesion Synthesis by POLH
Clathrin-mediated endocytosis
Regulation of RUNX2 expression and activity
APC-Cdc20 mediated degradation of Nek2A
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Negative regulation of FGFR4 signaling
Degradation of GLI1 by the proteasome
Downregulation of ERBB4 signaling
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
SCF(Skp2)-mediated degradation of p27/p21
Regulation of RAS by GAPs
Asymmetric localization of PCP proteins
Autodegradation of Cdh1 by Cdh1:APC/C
Translesion synthesis by POLK
Degradation of beta-catenin by the destruction complex
Gap-filling DNA repair synthesis and ligation in TC-NER
Autodegradation of the E3 ubiquitin ligase COP1
Stabilization of p53
APC/C:Cdc20 mediated degradation of Securin
G2/M Checkpoints
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Endosomal Sorting Complex Required For Transport (ESCRT)
E3 ubiquitin ligases ubiquitinate target proteins
Synthesis of active ubiquitin: roles of E1 and E2 enzymes
CDT1 association with the CDC6:ORC:origin complex
HDR through Homologous Recombination (HRR)
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Negative regulation of FGFR2 signaling
Dectin-1 mediated noncanonical NF-kB signaling
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
activated TAK1 mediates p38 MAPK activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of innate immune responses to cytosolic DNA
Oncogene Induced Senescence
p75NTR recruits signalling complexes
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
APC/C:Cdc20 mediated degradation of Cyclin B
Spry regulation of FGF signaling
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Activation of NF-kappaB in B cells
AUF1 (hnRNP D0) binds and destabilizes mRNA
Activated NOTCH1 Transmits Signal to the Nucleus
CDK-mediated phosphorylation and removal of Cdc6
CLEC7A (Dectin-1) signaling
Cyclin D associated events in G1
DNA Damage Recognition in GG-NER
Degradation of AXIN
Degradation of DVL
Deactivation of the beta-catenin transactivating complex
Downregulation of ERBB2:ERBB3 signaling
Downregulation of ERBB2 signaling
ER Quality Control Compartment (ERQC)
Downregulation of TGF-beta receptor signaling
Dual Incision in GG-NER
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Dual incision in TC-NER
Downstream TCR signaling
EGFR downregulation
Fanconi Anemia Pathway
Formation of TC-NER Pre-Incision Complex
Formation of Incision Complex in GG-NER
Hedgehog on state
Hedgehog ligand biogenesis
Interleukin-1 signaling
Iron uptake and transport
Josephin domain DUBs
MAPK6/MAPK4 signaling
Neddylation
Negative regulation of MET activity
NIK-->noncanonical NF-kB signaling
NF-kB is activated and signals survival
NOD1/2 Signaling Pathway
Orc1 removal from chromatin
Oxidative Stress Induced Senescence
Peroxisomal protein import
Pink/Parkin Mediated Mitophagy
Regulation of FZD by ubiquitination
Regulation of signaling by CBL
Regulation of TNFR1 signaling
Recognition of DNA damage by PCNA-containing replication complex
Regulation of PLK1 Activity at G2/M Transition
Regulation of expression of SLITs and ROBOs
Regulation of PTEN stability and activity
Regulation of RUNX3 expression and activity
Regulation of TP53 Degradation
Senescence-Associated Secretory Phenotype (SASP)
Separation of Sister Chromatids
TNFR1-induced NFkappaB signaling pathway
TCF dependent signaling in response to WNT
TNFR2 non-canonical NF-kB pathway
Termination of translesion DNA synthesis
UCH proteinases
Ub-specific processing proteases
Ubiquitin-dependent degradation of Cyclin D1


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000014517 usp5 / ubiquitin specific peptidase 5 (isopeptidase T) / P45974* / P56399* / ubiquitin specific peptidase 5*  / reaction






 

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