ENSDARG00000104573


Danio rerio

Features
Gene ID: ENSDARG00000104573
  
Biological name :slc12a2
  
Synonyms : slc12a2 / solute carrier family 12 (sodium/potassium/chloride transporter), member 2
  
Possible biological names infered from orthology : P55011 / solute carrier family 12 member 2
  
Species: Danio rerio
  
Chr. number: 10
Strand: 1
Band:
Gene start: 16225117
Gene end: 16310179
  
Corresponding Affymetrix probe sets: Dr.17930.1.S1_at (Zebrafish Array)   
  
Cross references: Ensembl peptide - ENSDARP00000105107
Ensembl peptide - ENSDARP00000135730
Ensembl peptide - ENSDARP00000131505
NCBI entrez gene - 415170     See in Manteia.
RefSeq - NM_001163654
RefSeq - XM_021479152
RefSeq Peptide - NP_001157126
swissprot - A0A0G2KGS0
swissprot - E7FG36
swissprot - A0A0G2KTI4
ZFIN ID - ZDB-GENE-040625-53
Ensembl - ENSDARG00000104573
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SLC12A2ENSGALG00000014690Gallus gallus
 P55011ENSG00000064651Homo sapiens
 Slc12a2ENSMUSG00000024597Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
slc12a3 / solute carrier family 12 (sodium/chloride transporter), member 3 / P55017* / P59158* / solute carrier family 12 member 3*ENSDARG0000001385544
slc12a10.1 / solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 1ENSDARG0000005531341
slc12a10.3 / slc12a10.3 solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 3ENSDARG0000005525339
slc12a10.2 / solute carrier family 12 (sodium/potassium/chloride transporters), member 10, tandem duplicate 2ENSDARG0000007117339
slc12a1 / solute carrier family 12 (sodium/potassium/chloride transporter), member 1 / Q13621* / solute carrier family 12 member 1*ENSDARG0000009809636
slc12a4 / solute carrier family 12 (potassium/chloride transporter), member 4 / Q9JIS8* / Q9UP95* / solute carrier family 12 member 4*ENSDARG0000001437825
slc12a7b / solute carrier family 12 (potassium/chloride transporter), member 7b / Q9WVL3* / Q9Y666* / SLC12A7* / solute carrier family 12 member 7*ENSDARG0000006205824
slc12a5b / solute carrier family 12 (potassium/chloride transporter), member 5b / Q91V14* / Q9H2X9* / SLC12A5* / solute carrier family 12 member 5*ENSDARG0000007818724
CABZ01063543.1 / P55011* / SLC12A2* / solute carrier family 12 member 2*ENSDARG0000011304524
slc12a7a / solute carrier family 12 (potassium/chloride transporter), member 7a / Q9WVL3* / Q9Y666* / SLC12A7* / solute carrier family 12 member 7*ENSDARG0000007375623
slc12a5a / solute carrier family 12 (potassium/chloride transporter), member 5a / Q91V14* / Q9H2X9* / SLC12A5* / solute carrier family 12 member 5*ENSDARG0000007581523
A2BFP5 / slc12a9 / solute carrier family 12, member 9 / Q99MR3* / Q9BXP2*ENSDARG0000006036621
zgc:153039ENSDARG0000010272421
slc12a8 / solute carrier family 12, member 8 / A0AV02* / Q8VI23* / solute carrier family 12 (potassium/chloride transporters), member 8*ENSDARG0000007438416
si:cabz01090193.1 / Q9UHW9* / Q924N4* / Gm21985* / SLC12A6* / solute carrier family 12 member 6*ENSDARG000001054855


Protein motifs (from Interpro)
Interpro ID Name
 IPR002443  Na/K/Cl co-transporter
 IPR002444  Na/K/Cl co-transporter 1
 IPR004841  Amino acid permease/ SLC12A domain
 IPR004842  SLC12A transporter family
 IPR013612  Amino acid permease, N-terminal
 IPR018491  SLC12A transporter, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0042472 inner ear morphogenesis IMP
 biological_processGO:0043583 ear development IMP
 biological_processGO:0048798 swim bladder inflation IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0072488 ammonium transmembrane transport IEA
 biological_processGO:1902476 chloride transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IDA
 cellular_componentGO:0016324 apical plasma membrane IBA
 molecular_functionGO:0005215 transporter activity IEA
 molecular_functionGO:0008519 ammonium transmembrane transporter activity IBA
 molecular_functionGO:0015377 cation:chloride symporter activity IEA


Pathways (from Reactome)
Pathway description
Cation-coupled Chloride cotransporters


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain quality , abnormal
brain morphology , abnormal
Show

 ZFA:0000051 otic vesicle otic vesicle morphology , abnormal
Show

 ZFA:0000076 swim bladder swim bladder increased length , abnormal
swim bladder increased volume , abnormal
Show

 ZFA:0000107 eye eye quality , abnormal
Show

 ZFA:0000135 notochord notochord morphology , abnormal
Show

 ZFA:0000155 somite somite morphology , abnormal
Show

 ZFA:0000168 anterior macula anterior macula morphology , abnormal
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 ZFA:0000217 inner ear inner ear quality , abnormal
inner ear decreased size , abnormal
inner ear collapsed , abnormal
inner ear morphology , abnormal
Show

 ZFA:0000282 sensory system sensory system quality , abnormal
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 ZFA:0000386 macula macula crowded , abnormal
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 ZFA:0000431 semicircular canal semicircular canal morphology , abnormal
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 ZFA:0001094 whole organism whole organism lethal (sensu genetics) , abnormal
whole organism viability , abnormal
whole organism balance , abnormal
whole organism movement behavioral quality , abnormal
whole organism unbalanced , abnormal
whole organism circling , abnormal
Show

 ZFA:0001206 intermediate mesoderm intermediate mesoderm morphology , abnormal
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 ZFA:0001439 anatomical system anatomical system quality , abnormal
Show

 ZFA:0009090 pigment cell pigment cell quality , abnormal
Show

 ZFA:0009091 melanocyte melanocyte area , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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