ENSG00000005700


Homo sapiens
proteinIBTKdomainankyrinkinasebtbpozregulatorchromosomecondensationsuperfamilyrepeat-containingregulationtyrosineactivitybindingrccrepeatbeta-lactamase-inhibitoriiskpphosphorylationreleasesequesteredcalciumioncytosolnucleusnucleoplasmcytoplasmmembrane

Features
Gene ID: ENSG00000005700
  
Biological name :IBTK
  
Synonyms : IBTK / inhibitor of Bruton tyrosine kinase / Q9P2D0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q14.1
Gene start: 82169983
Gene end: 82247754
  
Corresponding Affymetrix probe sets: 210970_s_at (Human Genome U133 Plus 2.0 Array)   215086_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000422136
Ensembl peptide - ENSP00000478891
Ensembl peptide - ENSP00000426405
Ensembl peptide - ENSP00000424634
Ensembl peptide - ENSP00000422762
Ensembl peptide - ENSP00000305721
NCBI entrez gene - 25998     See in Manteia.
OMIM - 606457
RefSeq - XM_006715454
RefSeq - NM_001300906
RefSeq - NM_015525
RefSeq - XM_006715453
RefSeq Peptide - NP_056340
RefSeq Peptide - NP_001287835
swissprot - H0Y9N7
swissprot - Q9P2D0
swissprot - D6R9F4
swissprot - E7EPI0
swissprot - E9PDR5
Ensembl - ENSG00000005700
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ibtkENSDARG00000074424Danio rerio
 IBTKENSGALG00000015864Gallus gallus
 IbtkENSMUSG00000035941Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
MYCBP2 / O75592 / MYC binding protein 2, E3 ubiquitin protein ligaseENSG0000000581023


Protein motifs (from Interpro)
Interpro ID Name
 IPR000210  BTB/POZ domain
 IPR000408  Regulator of chromosome condensation, RCC1
 IPR002110  Ankyrin repeat
 IPR009091  Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
 IPR011333  SKP1/BTB/POZ domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR036770  Ankyrin repeat-containing domain superfamily


Gene Ontology (GO)
nitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationregulation of biological qualitycellular localizationregulation of molecular functionnitrogen compoundnitrogen compound metabolic processcellular metabolicellular metabolic processprimary metabolicprimary metabolic processorganic substanceorganic substance metabolic processestablishment of establishment of localizationregulation of bioregulation of biological qualitycellular localizacellular localizationregulation of molregulation of molecular function
protein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingenzyme regulator activityprotein bindingprotein bindingenzyme regulator activityenzyme regulator activity
cellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0001933 negative regulation of protein phosphorylation IDA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IDA
 biological_processGO:0061099 negative regulation of protein tyrosine kinase activity IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0019901 protein kinase binding IDA
 molecular_functionGO:0030292 protein tyrosine kinase inhibitor activity IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr