ENSG00000008323


Homo sapiens

Features
Gene ID: ENSG00000008323
  
Biological name :PLEKHG6
  
Synonyms : pleckstrin homology and RhoGEF domain containing G6 / PLEKHG6 / Q3KR16
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.31
Gene start: 6310436
Gene end: 6328506
  
Corresponding Affymetrix probe sets: 220073_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000304640
Ensembl peptide - ENSP00000393194
Ensembl peptide - ENSP00000442836
Ensembl peptide - ENSP00000011684
Ensembl peptide - ENSP00000380185
NCBI entrez gene - 55200     See in Manteia.
OMIM - 611743
RefSeq - XM_017019555
RefSeq - NM_001144856
RefSeq - NM_001144857
RefSeq - NM_018173
RefSeq - XM_005253704
RefSeq - XM_006718985
RefSeq - XM_011520967
RefSeq Peptide - NP_001138328
RefSeq Peptide - NP_001138329
RefSeq Peptide - NP_060643
swissprot - Q3KR16
swissprot - F5H731
Ensembl - ENSG00000008323
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 plekhg6ENSDARG00000086056Danio rerio
 Q8R0J1ENSMUSG00000038167Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
O94827 / PLEKHG5 / pleckstrin homology and RhoGEF domain containing G5ENSG0000017168034
Q6ZR37 / PLEKHG7 / pleckstrin homology and RhoGEF domain containing G7ENSG0000018751011


Protein motifs (from Interpro)
Interpro ID Name
 IPR000219  Dbl homology (DH) domain
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR035899  Dbl homology (DH) domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0035023 regulation of Rho protein signal transduction IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0065009 regulation of molecular function IEA
 cellular_componentGO:0000922 spindle pole IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005813 centrosome IDA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005902 microvillus IEA
 cellular_componentGO:0030054 cell junction IDA
 cellular_componentGO:0032154 cleavage furrow IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005089 Rho guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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