ENSG00000011426


Homo sapiens

Features
Gene ID: ENSG00000011426
  
Biological name :ANLN
  
Synonyms : anillin actin binding protein / ANLN / Q9NQW6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: p14.2
Gene start: 36389806
Gene end: 36453791
  
Corresponding Affymetrix probe sets: 1552619_a_at (Human Genome U133 Plus 2.0 Array)   222608_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000404979
Ensembl peptide - ENSP00000400777
Ensembl peptide - ENSP00000406584
Ensembl peptide - ENSP00000413522
Ensembl peptide - ENSP00000413441
Ensembl peptide - ENSP00000265748
Ensembl peptide - ENSP00000379380
Ensembl peptide - ENSP00000397465
Ensembl peptide - ENSP00000398712
Ensembl peptide - ENSP00000399553
NCBI entrez gene - 54443     See in Manteia.
OMIM - 616027
RefSeq - XM_017012356
RefSeq - NM_001284301
RefSeq - NM_001284302
RefSeq - NM_018685
RefSeq - XM_006715746
RefSeq - XM_006715747
RefSeq - XM_017012354
RefSeq - XM_017012355
RefSeq Peptide - NP_001271230
RefSeq Peptide - NP_001271231
RefSeq Peptide - NP_061155
swissprot - C9JJT6
swissprot - C9J0G4
swissprot - H7C0Y6
swissprot - H7C167
swissprot - H7C1C2
swissprot - H7C1K5
swissprot - H7C3S1
swissprot - H7C3R2
swissprot - Q9NQW6
swissprot - A0A024RA49
Ensembl - ENSG00000011426
  
Related genetic diseases (OMIM): 616032 - Focal segmental glomerulosclerosis 8, 616032
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 anlnENSDARG00000060917Danio rerio
 ENSGALG00000043642Gallus gallus
 AnlnENSMUSG00000036777Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001849  Pleckstrin homology domain
 IPR011993  PH-like domain superfamily
 IPR012966  Anillin homology domain
 IPR031970  Anillin, N-terminal domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IDA
 biological_processGO:0000921 septin ring assembly TAS
 biological_processGO:0002244 hematopoietic progenitor cell differentiation IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007096 regulation of exit from mitosis TAS
 biological_processGO:0051301 cell division IEA
 biological_processGO:0090521 glomerular visceral epithelial cell migration IMP
 biological_processGO:1904172 positive regulation of bleb assembly IMP
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005826 actomyosin contractile ring IDA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005938 cell cortex IEA
 cellular_componentGO:0015629 actin cytoskeleton IDA
 cellular_componentGO:0030496 midbody IDA
 cellular_componentGO:0032059 bleb IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0099738 cell cortex region IDA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000006 Autosomal dominant inheritance "A mode of inheritance that is observed for traits related to a gene encoded on one of the autosomes (i.e., the human chromosomes 1-22) in which a trait manifests in heterozygotes. In the context of medical genetics, an autosomal dominant disorder is caused when a single copy of the mutant allele is present. Males and females are affected equally, and can both transmit the disorder with a risk of 50% for each child of inheriting the mutant allele." [HPO:curators]
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 HP:0000093 Proteinuria 
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 HP:0000097 Focal segmental glomerulosclerosis 
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 HP:0000100 Nephrotic syndrome 
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 HP:0003774 End stage renal disease 
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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