ENSG00000019144


Homo sapiens
domainregulationPHLDB1fhasuperfamilybindingforkhead-associatedpleckstrinhomologysmadph-likeaconitasefamilyfe-sclustersitegastrulationepithelialmesenchymaltransitionmicrotubulecytoskeletonorganizationbasementmembraneassemblyinvolvedembryonicbodymorphogenesis

Features
Gene ID: ENSG00000019144
  
Biological name :PHLDB1
  
Synonyms : PHLDB1 / pleckstrin homology like domain family B member 1 / Q86UU1
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: q23.3
Gene start: 118606440
Gene end: 118658038
  
Corresponding Affymetrix probe sets: 212134_at (Human Genome U133 Plus 2.0 Array)   216019_x_at (Human Genome U133 Plus 2.0 Array)   216102_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000431508
Ensembl peptide - ENSP00000354498
Ensembl peptide - ENSP00000435520
Ensembl peptide - ENSP00000482728
Ensembl peptide - ENSP00000481393
Ensembl peptide - ENSP00000478254
Ensembl peptide - ENSP00000469820
Ensembl peptide - ENSP00000348359
NCBI entrez gene - 23187     See in Manteia.
OMIM - 612834
RefSeq - XM_017017410
RefSeq - XM_011542708
RefSeq - XM_011542709
RefSeq - XM_011542710
RefSeq - XM_011542711
RefSeq - XM_011542713
RefSeq - XM_011542715
RefSeq - XM_017017407
RefSeq - XM_017017408
RefSeq - XM_017017409
RefSeq - NM_001144758
RefSeq - NM_001144759
RefSeq - NM_015157
RefSeq - XM_005271468
RefSeq - XM_005271469
RefSeq - XM_005271470
RefSeq - XM_005271471
RefSeq - XM_005271472
RefSeq - XM_005271473
RefSeq - XM_005271474
RefSeq - XM_005277680
RefSeq - XM_006718796
RefSeq - XM_006718797
RefSeq - XM_006718798
RefSeq - XM_006718799
RefSeq - XM_006718800
RefSeq - XM_006718801
RefSeq - XM_006718802
RefSeq - XM_006718803
RefSeq - XM_011542703
RefSeq - XM_011542704
RefSeq - XM_011542705
RefSeq - XM_011542706
RefSeq - XM_011542707
RefSeq Peptide - NP_001138231
RefSeq Peptide - NP_055972
RefSeq Peptide - NP_001138230
swissprot - A0A024R3H6
swissprot - A0A087WZL0
swissprot - Q86UU1
swissprot - A0A024R3F4
swissprot - A0A087WXY7
swissprot - A0A087WTZ7
Ensembl - ENSG00000019144
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 phldb1aENSDARG00000061093Danio rerio
 phldb1bENSDARG00000079378Danio rerio
 PHLDB1ENSGALG00000040030Gallus gallus
 Phldb1ENSMUSG00000048537Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PHLDB2 / Q86SQ0 / pleckstrin homology like domain family B member 2ENSG0000014482433
PHLDB3 / Q6NSJ2 / pleckstrin homology like domain family B member 3ENSG0000017653115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000253  Forkhead-associated (FHA) domain
 IPR001849  Pleckstrin homology domain
 IPR008984  SMAD/FHA domain superfamily
 IPR011993  PH-like domain superfamily
 IPR018136  Aconitase family, 4Fe-4S cluster binding site


Gene Ontology (GO)
anatomical structure developmentcellular developmental processcellular component organizationmicrotubule-based processcellular component biogenesisanatomical structure developmentcellular developmental processcellular component organizationmicrotubule-based processcellular component biogenesisanatomical structure developmentcellular developmental processcellular component organizationmicrotubule-based processcellular component biogenesisanatomical structure developmentcellular developmental processcellular component organizationmicrotubule-based processcellular component biogenesisanatomical structure developmentcellular developmental processcellular component organizationmicrotubule-based processcellular component biogenesisanatomical structure developmentcellular developmental processcellular component organizationmicrotubule-based processcellular component biogenesisanatomical structure developmentcellular developmental processcellular component organizationmicrotubule-based processcellular component biogenesisanatomical structure developmentcellular developmental processcellular component organizationmicrotubule-based processcellular component biogenesisanatomical structure developmentcellular developmental processcellular component organizationmicrotubule-based processcellular component biogenesisanatomical structure developmentcellular developmental processcellular component organizationmicrotubule-based processcellular component biogenesisanatomical structure developanatomical structure developmentcellular developmental procecellular developmental processcellular component organizatcellular component organizationmicrotubule-based processmicrotubule-based processcellular component biogenesicellular component biogenesis
protein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein bindingprotein binding
cellcellcellcellcellcellcellcellcellcellcellcell
TypeGO IDTermEv.Code
 biological_processGO:0010470 regulation of gastrulation IMP
 biological_processGO:0010717 regulation of epithelial to mesenchymal transition IMP
 biological_processGO:0070507 regulation of microtubule cytoskeleton organization IGI
 biological_processGO:1904261 positive regulation of basement membrane assembly involved in embryonic body morphogenesis IMP
 cellular_componentGO:0045180 basal cortex IDA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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