ENSG00000060971


Homo sapiens

Features
Gene ID: ENSG00000060971
  
Biological name :ACAA1
  
Synonyms : ACAA1 / acetyl-CoA acyltransferase 1 / P09110
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p22.2
Gene start: 38103129
Gene end: 38137242
  
Corresponding Affymetrix probe sets: 202025_x_at (Human Genome U133 Plus 2.0 Array)   214274_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000398172
Ensembl peptide - ENSP00000486920
Ensembl peptide - ENSP00000486456
Ensembl peptide - ENSP00000414021
Ensembl peptide - ENSP00000405785
Ensembl peptide - ENSP00000403124
Ensembl peptide - ENSP00000301810
Ensembl peptide - ENSP00000333664
Ensembl peptide - ENSP00000389226
Ensembl peptide - ENSP00000391078
Ensembl peptide - ENSP00000395183
Ensembl peptide - ENSP00000396485
NCBI entrez gene - 30     See in Manteia.
OMIM - 604054
RefSeq - NM_001607
RefSeq - XM_011533650
RefSeq - XM_006713123
RefSeq - NM_001130410
RefSeq - XM_006713122
RefSeq Peptide - NP_001598
RefSeq Peptide - NP_001123882
swissprot - P09110
swissprot - H7C131
swissprot - B4DVF4
swissprot - A0A140VJX0
swissprot - A0A024R2M6
swissprot - F2Z2Q6
swissprot - F2Z3P7
swissprot - H0Y4D4
swissprot - C9JDE9
Ensembl - ENSG00000060971
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 acaa1ENSDARG00000004687Danio rerio
 ACAA1ENSGALG00000005860Gallus gallus
 Acaa1aENSMUSG00000036138Mus musculus
 Acaa1bENSMUSG00000010651Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HADHB / P55084 / hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit betaENSG0000013802935


Protein motifs (from Interpro)
Interpro ID Name
 IPR002155  Thiolase
 IPR016039  Thiolase-like
 IPR020610  Thiolase, active site
 IPR020613  Thiolase, conserved site
 IPR020615  Thiolase, acyl-enzyme intermediate active site
 IPR020616  Thiolase, N-terminal
 IPR020617  Thiolase, C-terminal


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000038 very long-chain fatty acid metabolic process IMP
 biological_processGO:0006629 lipid metabolic process IEA
 biological_processGO:0006631 fatty acid metabolic process IEA
 biological_processGO:0006635 fatty acid beta-oxidation IMP
 biological_processGO:0008152 metabolic process IEA
 biological_processGO:0008206 bile acid metabolic process IMP
 biological_processGO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase TAS
 biological_processGO:0036109 alpha-linolenic acid metabolic process TAS
 biological_processGO:0043312 neutrophil degranulation TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005782 peroxisomal matrix TAS
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0035580 specific granule lumen TAS
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 molecular_functionGO:0003824 catalytic activity IEA
 molecular_functionGO:0003988 acetyl-CoA C-acyltransferase activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008775 acetate CoA-transferase activity EXP
 molecular_functionGO:0016401 palmitoyl-CoA oxidase activity IMP
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0016746 transferase activity, transferring acyl groups IEA
 molecular_functionGO:0016747 transferase activity, transferring acyl groups other than amino-acyl groups IEA


Pathways (from Reactome)
Pathway description
alpha-linolenic acid (ALA) metabolism
Beta-oxidation of very long chain fatty acids
Neutrophil degranulation
Peroxisomal protein import
TYSND1 cleaves peroxisomal proteins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000108733 PEX12 / O00623 / peroxisomal biogenesis factor 12  / complex / reaction
 ENSG00000139197 PEX5 / P50542 / peroxisomal biogenesis factor 5  / complex / reaction
 ENSG00000157911 PEX10 / O60683 / peroxisomal biogenesis factor 10  / complex / reaction
 ENSG00000162928 PEX13 / Q92968 / peroxisomal biogenesis factor 13  / complex / reaction
 ENSG00000142655 PEX14 / O75381 / peroxisomal biogenesis factor 14  / complex / reaction
 ENSG00000164751 PEX2 / P28328 / peroxisomal biogenesis factor 2  / complex / reaction
 ENSG00000156521 Q2T9J0 / TYSND1 / trypsin domain containing 1  / reaction
 ENSG00000112357 PEX7 / O00628 / peroxisomal biogenesis factor 7  / complex / reaction






 

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