ENSG00000064655


Homo sapiens

Features
Gene ID: ENSG00000064655
  
Biological name :EYA2
  
Synonyms : EYA2 / EYA transcriptional coactivator and phosphatase 2 / O00167
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 20
Strand: 1
Band: q13.12
Gene start: 46894624
Gene end: 47188844
  
Corresponding Affymetrix probe sets: 209692_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000349986
Ensembl peptide - ENSP00000483392
Ensembl peptide - ENSP00000417105
Ensembl peptide - ENSP00000395427
Ensembl peptide - ENSP00000321590
Ensembl peptide - ENSP00000333640
NCBI entrez gene - 2139     See in Manteia.
OMIM - 601654
RefSeq - XM_005260327
RefSeq - XM_017027721
RefSeq - NM_005244
RefSeq - NM_172110
RefSeq Peptide - NP_005235
RefSeq Peptide - NP_742108
swissprot - O00167
swissprot - E7ETN2
swissprot - B1AKW3
Ensembl - ENSG00000064655
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 eya2ENSDARG00000018984Danio rerio
 ENSGALG00000042523Gallus gallus
 EYA2ENSGALG00000004508Gallus gallus
 Eya2ENSMUSG00000017897Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
EYA1 / Q99502 / EYA transcriptional coactivator and phosphatase 1ENSG0000010431364
EYA4 / O95677 / EYA transcriptional coactivator and phosphatase 4ENSG0000011231959
EYA3 / Q99504 / EYA transcriptional coactivator and phosphatase 3ENSG0000015816139


Protein motifs (from Interpro)
Interpro ID Name
 IPR006545  EYA domain
 IPR028472  Eyes absent family
 IPR028473  Eyes absent homologue 2
 IPR036412  HAD-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006281 DNA repair IEA
 biological_processGO:0006325 chromatin organization IEA
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IEA
 biological_processGO:0006470 protein dephosphorylation IEA
 biological_processGO:0006974 cellular response to DNA damage stimulus IEA
 biological_processGO:0007275 multicellular organism development IEA
 biological_processGO:0007501 mesodermal cell fate specification TAS
 biological_processGO:0014706 striated muscle tissue development IEA
 biological_processGO:0016576 histone dephosphorylation IDA
 biological_processGO:0035335 peptidyl-tyrosine dephosphorylation IEA
 biological_processGO:0045739 positive regulation of DNA repair IBA
 biological_processGO:0097192 extrinsic apoptotic signaling pathway in absence of ligand IEA
 biological_processGO:0097345 mitochondrial outer membrane permeabilization IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IBA
 cellular_componentGO:0005634 nucleus IBA
 cellular_componentGO:0005654 nucleoplasm TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005829 cytosol IDA
 molecular_functionGO:0000287 magnesium ion binding IDA
 molecular_functionGO:0004721 phosphoprotein phosphatase activity IEA
 molecular_functionGO:0004725 protein tyrosine phosphatase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000149311 ATM / Q13315 / ATM serine/threonine kinase  / reaction






 

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