ENSG00000066136


Homo sapiens

Features
Gene ID: ENSG00000066136
  
Biological name :NFYC
  
Synonyms : NFYC / nuclear transcription factor Y subunit gamma / Q13952
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: p34.2
Gene start: 40691648
Gene end: 40771603
  
Corresponding Affymetrix probe sets: 1559218_s_at (Human Genome U133 Plus 2.0 Array)   202215_s_at (Human Genome U133 Plus 2.0 Array)   202216_x_at (Human Genome U133 Plus 2.0 Array)   211251_x_at (Human Genome U133 Plus 2.0 Array)   211797_s_at (Human Genome U133 Plus 2.0 Array)   238231_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000414299
Ensembl peptide - ENSP00000409219
Ensembl peptide - ENSP00000416403
Ensembl peptide - ENSP00000436710
Ensembl peptide - ENSP00000434404
Ensembl peptide - ENSP00000433820
Ensembl peptide - ENSP00000433413
Ensembl peptide - ENSP00000312617
Ensembl peptide - ENSP00000361734
Ensembl peptide - ENSP00000361736
Ensembl peptide - ENSP00000361737
Ensembl peptide - ENSP00000361738
Ensembl peptide - ENSP00000361754
Ensembl peptide - ENSP00000396620
Ensembl peptide - ENSP00000397647
Ensembl peptide - ENSP00000404427
Ensembl peptide - ENSP00000408315
Ensembl peptide - ENSP00000408867
NCBI entrez gene - 4802     See in Manteia.
OMIM - 605344
RefSeq - XM_017001369
RefSeq - NM_001308114
RefSeq - NM_001308115
RefSeq - NM_014223
RefSeq - XM_005270894
RefSeq - XM_005270895
RefSeq - XM_006710658
RefSeq - XM_006710660
RefSeq - XM_006710661
RefSeq - XM_006710662
RefSeq - XM_011541516
RefSeq - XM_011541517
RefSeq - XM_017001364
RefSeq - XM_017001365
RefSeq - XM_017001366
RefSeq - XM_017001367
RefSeq - XM_017001368
RefSeq - NM_001142587
RefSeq - NM_001142588
RefSeq - NM_001142589
RefSeq - NM_001142590
RefSeq Peptide - NP_001295044
RefSeq Peptide - NP_055038
RefSeq Peptide - NP_001295043
RefSeq Peptide - NP_001136059
RefSeq Peptide - NP_001136060
RefSeq Peptide - NP_001136061
RefSeq Peptide - NP_001136062
swissprot - Q5T6K7
swissprot - A0A0A0MT00
swissprot - Q13952
swissprot - E9PL11
swissprot - E9PJA8
swissprot - E9PI99
swissprot - H0Y803
swissprot - E9PQR2
swissprot - Q5T6K5
Ensembl - ENSG00000066136
  

This gene has been taged as a transcription factor by TFT
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 nfycENSDARG00000070151Danio rerio
 NFYCENSGALG00000003189Gallus gallus
 NfycENSMUSG00000032897Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
POLE4 / Q9NR33 / DNA polymerase epsilon 4, accessory subunitENSG000001153507


Protein motifs (from Interpro)
Interpro ID Name
 IPR003958  Transcription factor CBF/NF-Y/archaeal histone domain
 IPR009072  Histone-fold
 IPR027170  Transcriptional activator NFYC/HAP5 subunit


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006351 transcription, DNA-templated IEA
 biological_processGO:0006355 regulation of transcription, DNA-templated IDA
 biological_processGO:0006357 regulation of transcription by RNA polymerase II TAS
 biological_processGO:0006366 transcription by RNA polymerase II IEA
 biological_processGO:0006457 protein folding TAS
 biological_processGO:0045540 regulation of cholesterol biosynthetic process TAS
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0016602 CCAAT-binding factor complex IDA
 cellular_componentGO:0032993 protein-DNA complex IDA
 cellular_componentGO:0090575 RNA polymerase II transcription factor complex IDA
 molecular_functionGO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding IDA
 molecular_functionGO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
 molecular_functionGO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA
 molecular_functionGO:0003677 DNA binding IEA
 molecular_functionGO:0003700 DNA-binding transcription factor activity TAS
 molecular_functionGO:0003713 transcription coactivator activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008134 transcription factor binding IEA
 molecular_functionGO:0044212 transcription regulatory region DNA binding IEA
 molecular_functionGO:0046982 protein heterodimerization activity IEA


Pathways (from Reactome)
Pathway description
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
ATF4 activates genes
ATF6 (ATF6-alpha) activates chaperone genes


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000072310 P36956 / SREBF1 / sterol regulatory element binding transcription factor 1  / complex / reaction
 ENSG00000120837 NFYB / P25208 / nuclear transcription factor Y subunit beta  / complex
 ENSG00000001167 NFYA / P23511 / nuclear transcription factor Y subunit alpha  / complex
 ENSG00000185591 SP1 / P08047 / Sp1 transcription factor  / complex / reaction
 ENSG00000198911 Q12772 / SREBF2 / sterol regulatory element binding transcription factor 2  / complex / reaction






 

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contact: otassy@igbmc.fr