ENSG00000070031


Homo sapiens
regulationSCTreceptorsignalingsecretionbindingsecreting-proteincoupleddevelopmentactivitypancreaticjuiceextracellularglucagongipvipprecursorpathwaybraincamp-mediatedembryonicdigestivetractsomatostatingastrin-inducedgastricacidcellularcomponentregion

Features
Gene ID: ENSG00000070031
  
Biological name :SCT
  
Synonyms : P09683 / SCT / secretin
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: -1
Band: p15.5
Gene start: 626431
Gene end: 627143
  
Corresponding Affymetrix probe sets: 221198_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000176195
NCBI entrez gene - 6343     See in Manteia.
OMIM - 182099
RefSeq - NM_021920
RefSeq Peptide - NP_068739
swissprot - P09683
Ensembl - ENSG00000070031
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 SctENSMUSG00000038580Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000532  Glucagon/GIP/secretin/VIP
 IPR015675  Secretin precursor


Gene Ontology (GO)
cell communicationcellular response to stimulusanatomical structure developmentregulation of molecular functionestablishment of localizationregulation of biological qualitysystem processdigestioncell communicationcellular response to stimulusanatomical structure developmentregulation of molecular functionestablishment of localizationregulation of biological qualitysystem processdigestioncell communicationcellular response to stimulusanatomical structure developmentregulation of molecular functionestablishment of localizationregulation of biological qualitysystem processdigestioncell communicationcellular response to stimulusanatomical structure developmentregulation of molecular functionestablishment of localizationregulation of biological qualitysystem processdigestioncell communicationcellular response to stimulusanatomical structure developmentregulation of molecular functionestablishment of localizationregulation of biological qualitysystem processdigestioncell communicationcellular response to stimulusanatomical structure developmentregulation of molecular functionestablishment of localizationregulation of biological qualitysystem processdigestioncell communicationcellular response to stimulusanatomical structure developmentregulation of molecular functionestablishment of localizationregulation of biological qualitysystem processdigestioncell communicationcellular response to stimulusanatomical structure developmentregulation of molecular functionestablishment of localizationregulation of biological qualitysystem processdigestioncell communicationcellular response to stimulusanatomical structure developmentregulation of molecular functionestablishment of localizationregulation of biological qualitysystem processdigestioncell communicationcellular response to stimulusanatomical structure developmentregulation of molecular functionestablishment of localizationregulation of biological qualitysystem processdigestioncell communicatiocell communicationcellular responsecellular response to stimulusanatomical structanatomical structure developmentregulation of molregulation of molecular functionestablishment of establishment of localizationregulation of bioregulation of biological qualitysystem processsystem processdigestiondigestion
protein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingreceptor regulator activityprotein bindingprotein bindingreceptor regulator activityreceptor regulator activity
extracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007420 brain development IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030157 pancreatic juice secretion NAS
 biological_processGO:0043950 positive regulation of cAMP-mediated signaling IEA
 biological_processGO:0048566 embryonic digestive tract development IEA
 biological_processGO:0090187 positive regulation of pancreatic juice secretion IEA
 biological_processGO:0090274 positive regulation of somatostatin secretion IEA
 biological_processGO:1903640 negative regulation of gastrin-induced gastric acid secretion IEA
 cellular_componentGO:0005575 cellular_component ND
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IPI
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005179 hormone activity NAS
 molecular_functionGO:0047485 protein N-terminus binding IEA


Pathways (from Reactome)
Pathway description
G alpha (s) signalling events
Glucagon-type ligand receptors


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000080293 SCTR / P47872 / secretin receptor  / complex / reaction






 

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