ENSG00000071054


Homo sapiens

Features
Gene ID: ENSG00000071054
  
Biological name :MAP4K4
  
Synonyms : MAP4K4 / mitogen-activated protein kinase kinase kinase kinase 4 / O95819
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q11.2
Gene start: 101696850
Gene end: 101894689
  
Corresponding Affymetrix probe sets: 1558732_at (Human Genome U133 Plus 2.0 Array)   206571_s_at (Human Genome U133 Plus 2.0 Array)   218181_s_at (Human Genome U133 Plus 2.0 Array)   222547_at (Human Genome U133 Plus 2.0 Array)   222548_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392830
Ensembl peptide - ENSP00000389752
Ensembl peptide - ENSP00000396066
Ensembl peptide - ENSP00000489579
Ensembl peptide - ENSP00000487176
Ensembl peptide - ENSP00000486116
Ensembl peptide - ENSP00000414766
Ensembl peptide - ENSP00000409720
Ensembl peptide - ENSP00000403016
Ensembl peptide - ENSP00000281111
Ensembl peptide - ENSP00000303600
Ensembl peptide - ENSP00000313644
Ensembl peptide - ENSP00000314363
Ensembl peptide - ENSP00000343658
Ensembl peptide - ENSP00000387370
NCBI entrez gene - 9448     See in Manteia.
OMIM - 604666
RefSeq - XM_017005375
RefSeq - XM_017005357
RefSeq - XM_017005358
RefSeq - XM_017005359
RefSeq - XM_017005360
RefSeq - XM_017005361
RefSeq - XM_017005362
RefSeq - XM_017005363
RefSeq - XM_017005364
RefSeq - XM_017005365
RefSeq - XM_017005366
RefSeq - XM_017005367
RefSeq - XM_017005368
RefSeq - XM_017005369
RefSeq - XM_017005370
RefSeq - XM_017005371
RefSeq - XM_017005372
RefSeq - XM_017005373
RefSeq - XM_017005374
RefSeq - NM_001242559
RefSeq - NM_001242560
RefSeq - NM_004834
RefSeq - NM_145686
RefSeq - NM_145687
RefSeq - XM_005264048
RefSeq - XM_005264050
RefSeq - XM_005264052
RefSeq - XM_005264057
RefSeq - XM_005264058
RefSeq - XM_005264059
RefSeq - XM_005264060
RefSeq - XM_005264062
RefSeq - XM_005264063
RefSeq - XM_005264064
RefSeq - XM_005264065
RefSeq - XM_005264066
RefSeq - XM_005264068
RefSeq - XM_005264069
RefSeq - XM_005264071
RefSeq - XM_006712865
RefSeq - XM_006712868
RefSeq - XM_006712869
RefSeq - XM_017005349
RefSeq - XM_017005350
RefSeq - XM_017005351
RefSeq - XM_017005352
RefSeq - XM_017005353
RefSeq - XM_017005354
RefSeq - XM_017005355
RefSeq - XM_017005356
RefSeq Peptide - NP_663720
RefSeq Peptide - NP_004825
RefSeq Peptide - NP_663719
RefSeq Peptide - NP_001229488
RefSeq Peptide - NP_001229489
swissprot - A0A0D9SG62
swissprot - G3XAA2
swissprot - G5E948
swissprot - H7C0P6
swissprot - E7EX83
swissprot - H7C3Z6
swissprot - O95819
swissprot - A0A0D9SEY1
swissprot - H7C360
swissprot - E7ETN6
swissprot - E7ENQ1
swissprot - E7EN19
swissprot - C9J840
Ensembl - ENSG00000071054
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map4k4ENSDARG00000098670Danio rerio
 MAP4K4ENSGALG00000016781Gallus gallus
 Map4k4ENSMUSG00000026074Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
TNIK / Q9UKE5 / TRAF2 and NCK interacting kinaseENSG0000015431070
MINK1 / Q8N4C8 / misshapen like kinase 1ENSG0000014150365
NRK / Q7Z2Y5 / Nik related kinaseENSG0000012357235
MAP4K3 / Q8IVH8 / mitogen-activated protein kinase kinase kinase kinase 3ENSG0000001156621
MAP4K5 / mitogen-activated protein kinase kinase kinase kinase 5ENSG0000001298321
MAP4K1 / Q92918 / mitogen-activated protein kinase kinase kinase kinase 1ENSG0000010481419
MAP4K2 / Q12851 / mitogen-activated protein kinase kinase kinase kinase 2ENSG0000016806719
SLK / Q9H2G2 / STE20 like kinaseENSG0000006561317
STK10 / O94804 / serine/threonine kinase 10ENSG0000007278616


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR001180  Citron homology (CNH) domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000185 activation of MAPKKK activity IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0010977 negative regulation of neuron projection development IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0035556 intracellular signal transduction IDA
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0046328 regulation of JNK cascade IDA
 biological_processGO:0048812 neuron projection morphogenesis IBA
 biological_processGO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus IEA
 biological_processGO:0070571 negative regulation of neuron projection regeneration IEA
 cellular_componentGO:0005737 cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004111 creatine kinase activity IDA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0008349 MAP kinase kinase kinase kinase activity IBA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA


Pathways (from Reactome)
Pathway description
Oxidative Stress Induced Senescence


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2025
contact: otassy@igbmc.fr