ENSG00000074771


Homo sapiens
nadphNOX3domainoxidasemembranefad-bindingferricreductasegravityactivitycytochromebheavychainnadbindingtransmembranecomponent-likeferredoxinreductase-typeriboflavinsynthase-likebeta-barreltemperaturehomeostasisdetectionresponsesuperoxideaniongenerationotolith

Features
Gene ID: ENSG00000074771
  
Biological name :NOX3
  
Synonyms : NADPH oxidase 3 / NOX3 / Q9HBY0
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: -1
Band: q25.3
Gene start: 155395370
Gene end: 155455903
  
Corresponding Affymetrix probe sets: 221089_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000159060
NCBI entrez gene - 50508     See in Manteia.
OMIM - 607105
RefSeq - NM_015718
RefSeq Peptide - NP_056533
swissprot - Q9HBY0
Ensembl - ENSG00000074771
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 NOX3ENSGALG00000013659Gallus gallus
 Nox3ENSMUSG00000023802Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CYBB / P04839 / cytochrome b-245 beta chainENSG0000016516859
NOX1 / Q9Y5S8 / NADPH oxidase 1ENSG0000000795256
NOX4 / Q9NPH5 / NADPH oxidase 4ENSG0000008699136
DUOX1 / Q9NRD9 / dual oxidase 1ENSG0000013785729
NOX5 / Q96PH1 / NADPH oxidase 5ENSG0000025534628
DUOX2 / Q9NRD8 / dual oxidase 2ENSG0000014027927


Protein motifs (from Interpro)
Interpro ID Name
 IPR000778  Cytochrome b245, heavy chain
 IPR013112  FAD-binding 8
 IPR013121  Ferric reductase, NAD binding domain
 IPR013130  Ferric reductase transmembrane component-like domain
 IPR017927  Ferredoxin reductase-type FAD-binding domain
 IPR017938  Riboflavin synthase-like beta-barrel
 IPR029653  NADPH oxidase 3


Gene Ontology (GO)
regulation of biological qualityresponse to external stimulusdetection of stimulusresponse to abiotic stimuluscellular metabolic processanatomical structure developmentoxidation-reduction processregulation of biological qualityresponse to external stimulusdetection of stimulusresponse to abiotic stimuluscellular metabolic processanatomical structure developmentoxidation-reduction processregulation of biological qualityresponse to external stimulusdetection of stimulusresponse to abiotic stimuluscellular metabolic processanatomical structure developmentoxidation-reduction processregulation of biological qualityresponse to external stimulusdetection of stimulusresponse to abiotic stimuluscellular metabolic processanatomical structure developmentoxidation-reduction processregulation of biological qualityresponse to external stimulusdetection of stimulusresponse to abiotic stimuluscellular metabolic processanatomical structure developmentoxidation-reduction processregulation of biological qualityresponse to external stimulusdetection of stimulusresponse to abiotic stimuluscellular metabolic processanatomical structure developmentoxidation-reduction processregulation of biological qualityresponse to external stimulusdetection of stimulusresponse to abiotic stimuluscellular metabolic processanatomical structure developmentoxidation-reduction processregulation of biological qualityresponse to external stimulusdetection of stimulusresponse to abiotic stimuluscellular metabolic processanatomical structure developmentoxidation-reduction processregulation of biological qualityresponse to external stimulusdetection of stimulusresponse to abiotic stimuluscellular metabolic processanatomical structure developmentoxidation-reduction processregulation of biological qualityresponse to external stimulusdetection of stimulusresponse to abiotic stimuluscellular metabolic processanatomical structure developmentoxidation-reduction processregulation of biologregulation of biological qualityresponse to externalresponse to external stimulusdetection of stimuludetection of stimulusresponse to abiotic response to abiotic stimuluscellular metabolic pcellular metabolic processanatomical structureanatomical structure developmentoxidation-reduction oxidation-reduction process
oxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activityoxidoreductase activity
cellmembraneprotein-containing complexorganelleextracellular regioncellmembraneprotein-containing complexorganelleextracellular regioncellmembraneprotein-containing complexorganelleextracellular regioncellmembraneprotein-containing complexorganelleextracellular regioncellmembraneprotein-containing complexorganelleextracellular regioncellmembraneprotein-containing complexorganelleextracellular regioncellmembraneprotein-containing complexorganelleextracellular regioncellmembraneprotein-containing complexorganelleextracellular regioncellmembraneprotein-containing complexorganelleextracellular regioncellmembraneprotein-containing complexorganelleextracellular regioncellcellmembranemembraneprotein-containing complexprotein-containing complexorganelleorganelleextracellular regionextracellular region
TypeGO IDTermEv.Code
 biological_processGO:0001659 temperature homeostasis IEA
 biological_processGO:0009590 detection of gravity IEA
 biological_processGO:0009629 response to gravity IEA
 biological_processGO:0042554 superoxide anion generation IEA
 biological_processGO:0048840 otolith development IEA
 biological_processGO:0055114 oxidation-reduction process IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0043020 NADPH oxidase complex IEA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0016175 superoxide-generating NADPH oxidase activity IEA
 molecular_functionGO:0016491 oxidoreductase activity IEA


Pathways (from Reactome)
Pathway description
RHO GTPases Activate NADPH Oxidases


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000136238 RAC1 / P63000 / Rac family small GTPase 1  / complex / reaction
 ENSG00000051523 CYBA / P13498 / cytochrome b-245 alpha chain  / complex
 ENSG00000158517 NCF1 / P14598 / neutrophil cytosolic factor 1  / complex
 ENSG00000188747 NOXA1 / Q86UR1 / NADPH oxidase activator 1  / complex
 ENSG00000116701 NCF2 / P19878 / neutrophil cytosolic factor 2  / complex






 

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