ENSG00000074855


Homo sapiens
transportproteinmembraneANO8chlorideintracellularinsulin-likegrowthfactoranoctaminanoctamin-iontransmembranemodificationcellularmetabolicprocessendoplasmicreticulumlumenplasmaintegralcomponentcalciumactivatedchannelactivitystimuli-sensingchannelsregulation

Features
Gene ID: ENSG00000074855
  
Biological name :ANO8
  
Synonyms : ANO8 / anoctamin 8 / Q9HCE9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: -1
Band: p13.11
Gene start: 17323223
Gene end: 17334829
  
Corresponding Affymetrix probe sets: 1563549_a_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000159087
Ensembl peptide - ENSP00000469751
Ensembl peptide - ENSP00000486865
NCBI entrez gene - 57719     See in Manteia.
OMIM - 610216
RefSeq - XM_017027048
RefSeq - NM_020959
RefSeq Peptide - NP_066010
swissprot - Q9HCE9
swissprot - M0QYD2
Ensembl - ENSG00000074855
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ano8aENSDARG00000076265Danio rerio
 ano8bENSDARG00000077229Danio rerio
 ENSGALG00000036840Gallus gallus
 ENSGALG00000034615Gallus gallus
 Ano8ENSMUSG00000034863Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
ANO10 / Q9NW15 / anoctamin 10ENSG0000016074619
ANO4 / Q32M45 / anoctamin 4ENSG0000015157216
ANO2 / Q9NQ90 / anoctamin 2ENSG0000004761715
ANO3 / Q9BYT9 / anoctamin 3ENSG0000013434315
ANO5 / Q75V66 / anoctamin 5ENSG0000017171415
ANO6 / Q4KMQ2 / anoctamin 6ENSG0000017711915
ANO1 / Q5XXA6 / anoctamin 1ENSG0000013162014
ANO7 / Q6IWH7 / anoctamin 7ENSG0000014620514
ANO9 / A1A5B4 / anoctamin 9ENSG0000018510112


Protein motifs (from Interpro)
Interpro ID Name
 IPR007632  Anoctamin
 IPR031289  Anoctamin-8


Gene Ontology (GO)
establishment of localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizationnitrogen compound metabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processestablishment of localizatioestablishment of localizationnitrogen compound metabolic nitrogen compound metabolic processcellular metabolic processcellular metabolic processprimary metabolic processprimary metabolic processorganic substance metabolic organic substance metabolic process
transmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activitytransmembrane transporter activity
cellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellorganellemembrane-enclosed lumenmembranecellcellorganelleorganellemembrane-enclosed lumenmembrane-enclosed lumenmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0006821 chloride transport IMP
 biological_processGO:0034220 ion transmembrane transport TAS
 biological_processGO:0043687 post-translational protein modification TAS
 biological_processGO:0044267 cellular protein metabolic process TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen TAS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005229 intracellular calcium activated chloride channel activity TAS


Pathways (from Reactome)
Pathway description
Stimuli-sensing channels
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Post-translational protein phosphorylation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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