ENSG00000085511


Homo sapiens

Features
Gene ID: ENSG00000085511
  
Biological name :MAP3K4
  
Synonyms : MAP3K4 / mitogen-activated protein kinase kinase kinase 4 / Q9Y6R4
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 6
Strand: 1
Band: q26
Gene start: 160991727
Gene end: 161117385
  
Corresponding Affymetrix probe sets: 204089_x_at (Human Genome U133 Plus 2.0 Array)   216199_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000446303
Ensembl peptide - ENSP00000439377
Ensembl peptide - ENSP00000445018
Ensembl peptide - ENSP00000297332
Ensembl peptide - ENSP00000355886
Ensembl peptide - ENSP00000355887
Ensembl peptide - ENSP00000375986
Ensembl peptide - ENSP00000390508
NCBI entrez gene - 4216     See in Manteia.
OMIM - 602425
RefSeq - XM_017010869
RefSeq - NM_001291958
RefSeq - NM_001301072
RefSeq - NM_005922
RefSeq - NM_006724
RefSeq - XM_005266989
RefSeq Peptide - NP_005913
RefSeq Peptide - NP_006715
RefSeq Peptide - NP_001278887
RefSeq Peptide - NP_001288001
swissprot - F5H538
swissprot - J3KNB8
swissprot - F5H2S6
swissprot - F5H4R1
swissprot - F5H534
swissprot - Q9Y6R4
swissprot - F5H1X6
Ensembl - ENSG00000085511
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 map3k4ENSDARG00000104835Danio rerio
 MAP3K4ENSGALG00000020003Gallus gallus
 Map3k4ENSMUSG00000014426Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000719  Protein kinase domain
 IPR008271  Serine/threonine-protein kinase, active site
 IPR011009  Protein kinase-like domain superfamily
 IPR017441  Protein kinase, ATP binding site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0000186 activation of MAPKK activity IDA
 biological_processGO:0001890 placenta development IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0007346 regulation of mitotic cell cycle IBA
 biological_processGO:0010225 response to UV-C IMP
 biological_processGO:0010468 regulation of gene expression IEA
 biological_processGO:0016310 phosphorylation IEA
 biological_processGO:0019100 male germ-line sex determination IEA
 biological_processGO:0032212 positive regulation of telomere maintenance via telomerase IMP
 biological_processGO:0035556 intracellular signal transduction IEA
 biological_processGO:0042981 regulation of apoptotic process IBA
 biological_processGO:0043507 positive regulation of JUN kinase activity IEA
 biological_processGO:0051973 positive regulation of telomerase activity IMP
 biological_processGO:0060718 chorionic trophoblast cell differentiation IEA
 biological_processGO:1900745 positive regulation of p38MAPK cascade IDA
 biological_processGO:1904355 positive regulation of telomere capping IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0004674 protein serine/threonine kinase activity IEA
 molecular_functionGO:0004709 MAP kinase kinase kinase activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding IEA
 molecular_functionGO:0016301 kinase activity IEA
 molecular_functionGO:0016740 transferase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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