ENSG00000089009


Homo sapiens
ribosomalproteinRPL6translationlssubunitdecaymembraneribosomebindingdomainlargemrnacytoplasmicregulationtranscriptionrrnaprocessingtranslationalsrp-dependentcotranslationaltargetingviralendoplasmicreticulumcytosolexpressionnonsensemediatednmd

Features
Gene ID: ENSG00000089009
  
Biological name :RPL6
  
Synonyms : Q02878 / ribosomal protein L6 / RPL6
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q24.13
Gene start: 112405190
Gene end: 112418838
  
Corresponding Affymetrix probe sets: 200034_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449486
Ensembl peptide - ENSP00000448570
Ensembl peptide - ENSP00000476161
Ensembl peptide - ENSP00000202773
Ensembl peptide - ENSP00000403172
Ensembl peptide - ENSP00000446859
Ensembl peptide - ENSP00000446883
Ensembl peptide - ENSP00000448067
NCBI entrez gene - 6128     See in Manteia.
OMIM - 603703
RefSeq - XM_017019782
RefSeq - NM_000970
RefSeq - NM_001024662
RefSeq - NM_001320137
RefSeq - NM_001320138
RefSeq - NM_001320139
RefSeq - NM_001320140
RefSeq - NM_001320141
RefSeq - NM_001320142
RefSeq - XM_017019781
RefSeq Peptide - NP_001307071
RefSeq Peptide - NP_000961
RefSeq Peptide - NP_001019833
RefSeq Peptide - NP_001307066
RefSeq Peptide - NP_001307067
RefSeq Peptide - NP_001307068
RefSeq Peptide - NP_001307069
RefSeq Peptide - NP_001307070
swissprot - F8VU16
swissprot - Q02878
swissprot - U3KQR5
swissprot - A0A024RBK3
swissprot - F8VWR1
swissprot - F8VZ45
swissprot - F8VZA3
swissprot - F8VR69
Ensembl - ENSG00000089009
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rpl6ENSDARG00000058451Danio rerio
 RPL6ENSGALG00000004818Gallus gallus
 Rpl6ENSMUSG00000029614Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000915  60S ribosomal protein L6E
 IPR005568  Ribosomal protein L6, N-terminal
 IPR008991  Translation protein SH3-like domain superfamily
 IPR014722  Ribosomal protein L2, domain 2


Gene Ontology (GO)
cellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular component organizationcellular component biogenesisnitrogen compound metabolic processcatabolic processcellular metabolic processprimary metabolic processorganic substance metabolic processbiosynthetic processmacromolecule localizationestablishment of localizationcellular localizationinterspecies interaction between organismscellular cocellular component organizationcellular cocellular component biogenesisnitrogen conitrogen compound metabolic processcatabolic pcatabolic processcellular mecellular metabolic processprimary metprimary metabolic processorganic suborganic substance metabolic processbiosynthetibiosynthetic processmacromolecumacromolecule localizationestablishmeestablishment of localizationcellular locellular localizationinterspecieinterspecies interaction between organisms
organic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomeprotein bindingorganic cyclic compound bindingorganic cyclic compound bindingheterocyclic compound bindingheterocyclic compound bindingstructural constituent of ribosomestructural constituent of ribosomeprotein bindingprotein binding
cellorganelleprotein-containing complexcell junctionmembranecellorganelleprotein-containing complexcell junctionmembranecellorganelleprotein-containing complexcell junctionmembranecellorganelleprotein-containing complexcell junctionmembranecellorganelleprotein-containing complexcell junctionmembranecellorganelleprotein-containing complexcell junctionmembranecellorganelleprotein-containing complexcell junctionmembranecellorganelleprotein-containing complexcell junctionmembranecellorganelleprotein-containing complexcell junctionmembranecellorganelleprotein-containing complexcell junctionmembranecellcellorganelleorganelleprotein-containing complexprotein-containing complexcell junctioncell junctionmembranemembrane
TypeGO IDTermEv.Code
 biological_processGO:0000027 ribosomal large subunit assembly IBA
 biological_processGO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
 biological_processGO:0002181 cytoplasmic translation IBA
 biological_processGO:0006355 regulation of transcription, DNA-templated TAS
 biological_processGO:0006364 rRNA processing TAS
 biological_processGO:0006412 translation IEA
 biological_processGO:0006413 translational initiation TAS
 biological_processGO:0006614 SRP-dependent cotranslational protein targeting to membrane TAS
 biological_processGO:0019083 viral transcription TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0005840 ribosome IEA
 cellular_componentGO:0005925 focal adhesion HDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0022625 cytosolic large ribosomal subunit TAS
 cellular_componentGO:0036464 cytoplasmic ribonucleoprotein granule IDA
 cellular_componentGO:0042788 polysomal ribosome IDA
 molecular_functionGO:0003677 DNA binding TAS
 molecular_functionGO:0003723 RNA binding TAS
 molecular_functionGO:0003735 structural constituent of ribosome IEA
 molecular_functionGO:0045296 cadherin binding IDA


Pathways (from Reactome)
Pathway description
L13a-mediated translational silencing of Ceruloplasmin expression
Peptide chain elongation
SRP-dependent cotranslational protein targeting to membrane
Viral mRNA Translation
Selenocysteine synthesis
Major pathway of rRNA processing in the nucleolus and cytosol
Formation of a pool of free 40S subunits
GTP hydrolysis and joining of the 60S ribosomal subunit
Eukaryotic Translation Termination
Regulation of expression of SLITs and ROBOs
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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